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Weak to moderate cytoplasmic staining in several cases of colorectal, stomach, liver, thyroid, and female genital cancers. Remaining cancers were generally negative.
Distinct staining of connective tissues and blood vessels in most cancer tissues. Weak cytoplasmic staining in several colorectal cancers. Single cases of a few remaining cancers were also positive. Cancer cells in general were negative.
Endothelial cells in subsets of vessels showed moderate to strong cytoplasmic and membranous positivity in most cancer tissues.
GENE INFORMATION
Gene name
ENG (HGNC Symbol)
Synonyms
CD105, END, HHT1, ORW, ORW1
Description
Endoglin (HGNC Symbol)
Entrez gene summary
This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds to the beta1 and beta3 peptides with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. This gene may also be involved in preeclampsia and several types of cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013]