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AK1

GENERAL INFORMATION

Gene name

 AK1

Gene description

 Adenylate kinase 1

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression at variable levels in several different cell types, most abundant in fallopian tube, Leydig cells and skeletal muscle.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 2 antibodies.
HPA006456 , CAB009893
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PROGNOSTIC SUMMARY
Prognostic marker in stomach cancer (favourable).
Stomach cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Thyroid cancer

STAINING SUMMARY
HPA006456
CAB009893

GENE INFORMATION

Gene name

 AK1

Synonyms

Description

 Adenylate kinase 1 (HGNC Symbol)

Entrez gene summary

 Adenylate kinase is an enzyme involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate group among adinine nucleotides. Three isozymes of adenylate kinase have been identified in vertebrates, adenylate isozyme 1 (AK1), 2 (AK2) and 3 (AK3). AK1 is found in the cytosol of skeletal muscle, brain and erythrocytes, whereas AK2 and AK3 are found in the mitochondria of other tissues including liver and heart. AK1 was identified because of its association with a rare genetic disorder causing nonspherocytic hemolytic anemia where a mutation in the AK1 gene was found to reduce the catalytic activity of the enzyme. [provided by RefSeq, Jul 2008]

Chromosome

 9

Cytoband

 q34.11

Chromosome location (bp)

 127866480 - 127877743

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000106992 (version 83.38)

Entrez gene

 203

UniProt

 P00568 (UniProt - Evidence at protein level)

neXtProt

 NX_P00568

Antibodypedia

 AK1 antibodies

PROTEIN BROWSER
AK1-008
AK1-009
AK1-010
AK1-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AK1-008
ENSP00000362271
ENST00000373176
P00568 [Direct mapping]
Adenylate kinase isoenzyme 1
Q6FGX9 [Target identity:100%; Query identity:100%]
Adenylate kinase isoenzyme 1
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001520 [outer dense fiber]
GO:0004017 [adenylate kinase activity]
GO:0004550 [nucleoside diphosphate kinase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006165 [nucleoside diphosphate phosphorylation]
GO:0006172 [ADP biosynthetic process]
GO:0007050 [cell cycle arrest]
GO:0009142 [nucleoside triphosphate biosynthetic process]
GO:0015949 [nucleobase-containing small molecule interconversion]
GO:0019205 [nucleobase-containing compound kinase activity]
GO:0036126 [sperm flagellum]
GO:0044281 [small molecule metabolic process]
GO:0046033 [AMP metabolic process]
GO:0046034 [ATP metabolic process]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0070062 [extracellular exosome]
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 194 aa
21.6 kDa 		No 0
AK1-009
ENSP00000223836
ENST00000223836
Q5T9B7 [Direct mapping]
Adenylate kinase isoenzyme 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0004017 [adenylate kinase activity]
GO:0004550 [nucleoside diphosphate kinase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006165 [nucleoside diphosphate phosphorylation]
GO:0006172 [ADP biosynthetic process]
GO:0009142 [nucleoside triphosphate biosynthetic process]
GO:0019205 [nucleobase-containing compound kinase activity]
GO:0046033 [AMP metabolic process]
GO:0046034 [ATP metabolic process]
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 210 aa
23.4 kDa 		No 0
AK1-010
ENSP00000362249
ENST00000373156
P00568 [Direct mapping]
Adenylate kinase isoenzyme 1
Q6FGX9 [Target identity:100%; Query identity:100%]
Adenylate kinase isoenzyme 1
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004017 [adenylate kinase activity]
GO:0004550 [nucleoside diphosphate kinase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006165 [nucleoside diphosphate phosphorylation]
GO:0006172 [ADP biosynthetic process]
GO:0009142 [nucleoside triphosphate biosynthetic process]
GO:0015949 [nucleobase-containing small molecule interconversion]
GO:0019205 [nucleobase-containing compound kinase activity]
GO:0044281 [small molecule metabolic process]
GO:0046033 [AMP metabolic process]
GO:0046034 [ATP metabolic process]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0070062 [extracellular exosome]
Show all
 194 aa
21.6 kDa 		No 0
AK1-011
ENSP00000392314
ENST00000413016
H0Y4J6 [Direct mapping]
Adenylate kinase isoenzyme 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0016310 [phosphorylation]
GO:0019205 [nucleobase-containing compound kinase activity]
Show all
 135 aa
15.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.