Expression of RIC1 in cancer - Summary - The Human Protein Atlas

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RIC1

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	RIC1
Gene description	RIC1 homolog, RAB6A GEF complex partner 1
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous membranous expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA051578
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA051578

GENE INFORMATION
Gene name	RIC1 (HGNC Symbol)
Synonyms	bA207C16.1, KIAA1432
Description	RIC1 homolog, RAB6A GEF complex partner 1 (HGNC Symbol)
Entrez gene summary
Chromosome	9
Cytoband	p24.1
Chromosome location (bp)	5629025 - 5776557
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000107036 (version 83.38)
Entrez gene	57589
UniProt	Q4ADV7 (UniProt - Evidence at protein level)
neXtProt	NX_Q4ADV7
Antibodypedia	RIC1 antibodies

PROTEIN BROWSER

RIC1-001	RIC1-002	RIC1-003	RIC1-005	RIC1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RIC1-001 ENSP00000251879 ENST00000251879	Q4ADV7 [Direct mapping] RAB6A-GEF complex partner protein 1 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017112 [Rab guanyl-nucleotide exchange factor activity] GO:0017137 [Rab GTPase binding] GO:0034066 [RIC1-RGP1 guanyl-nucleotide exchange factor complex] GO:0042147 [retrograde transport, endosome to Golgi] GO:0043234 [protein complex] GO:0043547 [positive regulation of GTPase activity] GO:1903363 [negative regulation of cellular protein catabolic process] Show all	1165 aa 131.2 kDa	No	0
RIC1-002 ENSP00000416696 ENST00000414202	Q4ADV7 [Direct mapping] RAB6A-GEF complex partner protein 1 Show all	MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017112 [Rab guanyl-nucleotide exchange factor activity] GO:0017137 [Rab GTPase binding] GO:0034066 [RIC1-RGP1 guanyl-nucleotide exchange factor complex] GO:0042147 [retrograde transport, endosome to Golgi] GO:0043234 [protein complex] GO:0043547 [positive regulation of GTPase activity] GO:1903363 [negative regulation of cellular protein catabolic process] Show all	1423 aa 159.3 kDa	No	0
RIC1-003 ENSP00000439488 ENST00000545641	H0YFN7 [Direct mapping] RAB6A-GEF complex partner protein 1 Show all	MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	1315 aa 147.1 kDa	No	0
RIC1-005 ENSP00000438005 ENST00000490816	H0YFD4 [Direct mapping] RAB6A-GEF complex partner protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all		147 aa 16.3 kDa	No	1
RIC1-201 ENSP00000402240 ENST00000418622	Q4ADV7 [Direct mapping] RAB6A-GEF complex partner protein 1 Show all	MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017112 [Rab guanyl-nucleotide exchange factor activity] GO:0017137 [Rab GTPase binding] GO:0034066 [RIC1-RGP1 guanyl-nucleotide exchange factor complex] GO:0042147 [retrograde transport, endosome to Golgi] GO:0043234 [protein complex] GO:0043547 [positive regulation of GTPase activity] GO:1903363 [negative regulation of cellular protein catabolic process] Show all	1386 aa 155.2 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.