Expression of DOCK8 in cancer - Summary - The Human Protein Atlas

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DOCK8

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DOCK8
Gene description	Dedicator of cytokinesis 8
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (NB-4, REH, THP-1)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and/or nuclear expression in selected tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA003218
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (favourable) and renal cancer (favourable).
Urothelial cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

Cervical cancer

STAINING SUMMARY

HPA003218

GENE INFORMATION
Gene name	DOCK8 (HGNC Symbol)
Synonyms	FLJ00026, FLJ00152, FLJ00346, ZIR8
Description	Dedicator of cytokinesis 8 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the DOCK180 family of guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with Rho GTPases and are components of intracellular signaling networks. Mutations in this gene result in the autosomal recessive form of the hyper-IgE syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Jun 2010]
Chromosome	9
Cytoband	p24.3
Chromosome location (bp)	214854 - 465259
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000107099 (version 83.38)
Entrez gene	81704
UniProt	Q8NF50 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NF50
Antibodypedia	DOCK8 antibodies

PROTEIN BROWSER

DOCK8-001	DOCK8-005	DOCK8-009	DOCK8-012	DOCK8-013	DOCK8-014	DOCK8-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DOCK8-001 ENSP00000394888 ENST00000432829	Q8NF50 [Direct mapping] Dedicator of cytokinesis protein 8 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001771 [immunological synapse formation] GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0007264 [small GTPase mediated signal transduction] GO:0007596 [blood coagulation] GO:0016020 [membrane] GO:0031252 [cell leading edge] GO:0036336 [dendritic cell migration] GO:0043547 [positive regulation of GTPase activity] GO:0061485 [memory T cell proliferation] GO:0070233 [negative regulation of T cell apoptotic process] Show all	2099 aa 238.5 kDa	No	0
DOCK8-005 ENSP00000371766 ENST00000382329	A2A369 [Direct mapping] Dedicator of cytokinesis protein 8 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005488 [binding] GO:0005622 [intracellular] GO:0007264 [small GTPase mediated signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	1566 aa 178 kDa	No	0
DOCK8-009 ENSP00000371768 ENST00000382331	A2A370 [Direct mapping] Dedicator of cytokinesis protein 8 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005622 [intracellular] GO:0007264 [small GTPase mediated signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	439 aa 49.5 kDa	No	0
DOCK8-012 ENSP00000419438 ENST00000469391	Q8NF50 [Direct mapping] Dedicator of cytokinesis protein 8 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0007264 [small GTPase mediated signal transduction] GO:0007596 [blood coagulation] GO:0016020 [membrane] GO:0043547 [positive regulation of GTPase activity] GO:0061485 [memory T cell proliferation] Show all	1999 aa 227.5 kDa	No	0
DOCK8-013 ENSP00000417082 ENST00000479404	C9J613 [Direct mapping] Dedicator of cytokinesis protein 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005622 [intracellular] GO:0007264 [small GTPase mediated signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	66 aa 7.7 kDa	No	0
DOCK8-014 ENSP00000418318 ENST00000487230	C9J7A3 [Direct mapping] Dedicator of cytokinesis protein 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005622 [intracellular] GO:0007264 [small GTPase mediated signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	107 aa 12.2 kDa	No	0
DOCK8-201 ENSP00000408464 ENST00000453981	Q8NF50 [Direct mapping] Dedicator of cytokinesis protein 8 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0007264 [small GTPase mediated signal transduction] GO:0007596 [blood coagulation] GO:0016020 [membrane] GO:0043547 [positive regulation of GTPase activity] GO:0061485 [memory T cell proliferation] Show all	2031 aa 230.8 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.