Expression of ELAVL2 in cancer - Summary - The Human Protein Atlas

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ELAVL2

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ELAVL2
Gene description	ELAV like neuron-specific RNA binding protein 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (testis cancer)
HPA (cell line):	Cell line enhanced (AF22, SCLC-21H)
HPA (normal tissue):	Group enriched (cerebral cortex, testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in CNS and cells in seminiferous ducts.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 2 antibodies. HPA063001 , CAB022222
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (testis cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA063001	CAB022222

GENE INFORMATION
Gene name	ELAVL2 (HGNC Symbol)
Synonyms	HEL-N1, HuB
Description	ELAV like neuron-specific RNA binding protein 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a neural-specific RNA-binding protein that is known to bind to several 3' UTRs, including its own and also that of FOS and ID. The encoded protein may recognize a GAAA motif in the RNA. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
Chromosome	9
Cytoband	p21.3
Chromosome location (bp)	23690104 - 23826337
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000107105 (version 83.38)
Entrez gene	1993
UniProt	Q12926 (UniProt - Evidence at protein level)
neXtProt	NX_Q12926
Antibodypedia	ELAVL2 antibodies

PROTEIN BROWSER

ELAVL2-001	ELAVL2-002	ELAVL2-003	ELAVL2-004	ELAVL2-005	ELAVL2-201	ELAVL2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ELAVL2-001 ENSP00000369460 ENST00000380117	Q12926 [Direct mapping] ELAV-like protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0003730 [mRNA 3'-UTR binding] GO:0005515 [protein binding] GO:0006355 [regulation of transcription, DNA-templated] GO:0044822 [poly(A) RNA binding] Show all	359 aa 39.5 kDa	No	0
ELAVL2-002 ENSP00000223951 ENST00000223951	Q12926 [Direct mapping] ELAV-like protein 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0003730 [mRNA 3'-UTR binding] GO:0005515 [protein binding] GO:0006355 [regulation of transcription, DNA-templated] GO:0044822 [poly(A) RNA binding] Show all	346 aa 38 kDa	No	0
ELAVL2-003 ENSP00000412602 ENST00000440102	B1AM48 [Direct mapping] ELAV-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] Show all	189 aa 20.7 kDa	No	0
ELAVL2-004 ENSP00000369453 ENST00000380110	A0A0A0MRX1 [Direct mapping] ELAV-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] Show all	389 aa 42.6 kDa	No	0
ELAVL2-005 ENSP00000391757 ENST00000423281	C9JB16 [Direct mapping] ELAV-like protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] Show all	90 aa 10.1 kDa	No	0
ELAVL2-201 ENSP00000380479 ENST00000397312	Q12926 [Direct mapping] ELAV-like protein 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0003730 [mRNA 3'-UTR binding] GO:0005515 [protein binding] GO:0006355 [regulation of transcription, DNA-templated] GO:0044822 [poly(A) RNA binding] Show all	359 aa 39.5 kDa	No	0
ELAVL2-202 ENSP00000440998 ENST00000544538	Q12926 [Direct mapping] ELAV-like protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0003730 [mRNA 3'-UTR binding] GO:0005515 [protein binding] GO:0006355 [regulation of transcription, DNA-templated] GO:0044822 [poly(A) RNA binding] Show all	359 aa 39.5 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.