Expression of CA9 in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CA9
Gene description	Carbonic anhydrase IX
Protein class	Enzymes Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Group enriched (A-431, HDLM-2, U-87 MG)
HPA (normal tissue):	Tissue enhanced (gallbladder, stomach)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Highly selective membranous expression in the gastrointestinal mucosa and gall bladder.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 3 antibodies. HPA055207 , CAB005100 , CAB017107
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), liver cancer (unfavourable) and testis cancer (favourable).
Renal cancer p<0.001 Liver cancer p<0.001 Testis cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

STAINING SUMMARY

HPA055207	CAB005100	CAB017107

GENE INFORMATION
Gene name	CA9 (HGNC Symbol)
Synonyms	CAIX, MN
Description	Carbonic anhydrase IX (HGNC Symbol)
Entrez gene summary	Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and is one of only two tumor-associated carbonic anhydrase isoenzymes known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12. [provided by RefSeq, Jun 2014]
Chromosome	9
Cytoband	p13.3
Chromosome location (bp)	35673856 - 35681159
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000107159 (version 83.38)
Entrez gene	768
UniProt	Q16790 (UniProt - Evidence at protein level)
neXtProt	NX_Q16790
Antibodypedia	CA9 antibodies

PROTEIN BROWSER

CA9-001	CA9-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CA9-001 ENSP00000367608 ENST00000378357	Q16790 [Direct mapping] Carbonic anhydrase 9 Show all	Enzymes ENZYME proteins Lyases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001666 [response to hypoxia] GO:0002009 [morphogenesis of an epithelium] GO:0004089 [carbonate dehydratase activity] GO:0005730 [nucleolus] GO:0005886 [plasma membrane] GO:0006730 [one-carbon metabolic process] GO:0008270 [zinc ion binding] GO:0015701 [bicarbonate transport] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0031528 [microvillus membrane] GO:0033574 [response to testosterone] GO:0042493 [response to drug] GO:0044281 [small molecule metabolic process] GO:0046903 [secretion] GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0071456 [cellular response to hypoxia] Show all	459 aa 49.7 kDa	Yes	1
CA9-201 ENSP00000482050 ENST00000617161	A0A087WYS4 [Direct mapping] Carbonic anhydrase 9 Show all	MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004089 [carbonate dehydratase activity] GO:0006730 [one-carbon metabolic process] GO:0008270 [zinc ion binding] Show all	356 aa 38.7 kDa	Yes	0