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RGP1

GENERAL INFORMATION

Gene name

 RGP1

Gene description

 RGP1 homolog, RAB6A GEF complex partner 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression at variable levels in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA020414 , HPA021085
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and liver cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Ovarian cancer

STAINING SUMMARY
HPA020414
HPA021085

GENE INFORMATION

Gene name

 RGP1 (HGNC Symbol)

Synonyms

 KIAA0258

Description

 RGP1 homolog, RAB6A GEF complex partner 1 (HGNC Symbol)

Entrez gene summary

Chromosome

 9

Cytoband

 p13.3

Chromosome location (bp)

 35749287 - 35758575

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000107185 (version 83.38)

Entrez gene

 9827

UniProt

 Q92546 (UniProt - Evidence at protein level)

neXtProt

 NX_Q92546

Antibodypedia

 RGP1 antibodies

PROTEIN BROWSER
RGP1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RGP1-001
ENSP00000367318
ENST00000378078
Q92546 [Direct mapping]
RAB6A-GEF complex partner protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0016020 [membrane]
GO:0017112 [Rab guanyl-nucleotide exchange factor activity]
GO:0017137 [Rab GTPase binding]
GO:0034066 [RIC1-RGP1 guanyl-nucleotide exchange factor complex]
GO:0042147 [retrograde transport, endosome to Golgi]
GO:0043234 [protein complex]
GO:0043547 [positive regulation of GTPase activity]
GO:1903363 [negative regulation of cellular protein catabolic process]
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 391 aa
42.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.