Fields »
ABOUT
HELP
BLOG
BAG1

GENERAL INFORMATION

Gene name

 BAG1

Gene description

 BCL2-associated athanogene

Protein class

 Cancer-related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA018121 , CAB002486
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Carcinoid

STAINING SUMMARY
HPA018121
CAB002486

GENE INFORMATION

Gene name

 BAG1

Synonyms

Description

 BCL2-associated athanogene (HGNC Symbol)

Entrez gene summary

 The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. Multiple protein isoforms are encoded by this mRNA through the use of a non-AUG (CUG) initiation codon, and three alternative downstream AUG initiation codons. A related pseudogene has been defined on chromosome X. [provided by RefSeq, Feb 2010]

Chromosome

 9

Cytoband

 p13.3

Chromosome location (bp)

 33247820 - 33264761

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000107262 (version 83.38)

Entrez gene

 573

UniProt

 Q99933 (UniProt - Evidence at protein level)

neXtProt

 NX_Q99933

Antibodypedia

 BAG1 antibodies

PROTEIN BROWSER
BAG1-001
BAG1-005
BAG1-010
BAG1-011
BAG1-012
BAG1-013
BAG1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BAG1-001
ENSP00000489189
ENST00000634734
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0051087 [chaperone binding]
Show all
 345 aa
38.8 kDa 		No 0
BAG1-005
ENSP00000489401
ENST00000473464
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 63 aa
7.2 kDa 		No 0
BAG1-010
ENSP00000417576
ENST00000488499
C9J9Y9 [Direct mapping]
BAG family molecular chaperone regulator 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 48 aa
5.6 kDa 		No 0
BAG1-011
ENSP00000419092
ENST00000473781
C9JYK5 [Direct mapping]
BAG family molecular chaperone regulator 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0051087 [chaperone binding]
Show all
 150 aa
16.7 kDa 		No 0
BAG1-012
ENSP00000488937
ENST00000635077
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 94 aa
10.5 kDa 		No 0
BAG1-013
ENSP00000369026
ENST00000379704
Q99933 [Direct mapping]
BAG family molecular chaperone regulator 1
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005057 [receptor signaling protein activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0007166 [cell surface receptor signaling pathway]
GO:0034605 [cellular response to heat]
GO:0035556 [intracellular signal transduction]
GO:0043066 [negative regulation of apoptotic process]
GO:0051087 [chaperone binding]
GO:0070389 [chaperone cofactor-dependent protein refolding]
GO:1900034 [regulation of cellular response to heat]
Show all
 230 aa
26 kDa 		No 0
BAG1-201
ENSP00000420514
ENST00000472232
J3QTA2 [Direct mapping]
BAG family molecular chaperone regulator 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001933 [negative regulation of protein phosphorylation]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0030182 [neuron differentiation]
GO:0043066 [negative regulation of apoptotic process]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0051087 [chaperone binding]
GO:0051219 [phosphoprotein binding]
GO:0070585 [protein localization to mitochondrion]
GO:2000672 [negative regulation of motor neuron apoptotic process]
Show all
 345 aa
38.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.