Expression of NPDC1 in cancer - Summary - The Human Protein Atlas

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NPDC1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NPDC1
Gene description	Neural proliferation, differentiation and control, 1
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cyytoplasmic expression at variable levels in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA008189
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PROGNOSTIC SUMMARY
Prognostic marker in colorectal cancer (unfavourable), endometrial cancer (favourable) and pancreatic cancer (favourable).
Colorectal cancer p<0.001 Endometrial cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA008189

GENE INFORMATION
Gene name	NPDC1 (HGNC Symbol)
Synonyms	CAB-, CAB1, DKFZp586J0523
Description	Neural proliferation, differentiation and control, 1 (HGNC Symbol)
Entrez gene summary
Chromosome	9
Cytoband	q34.3
Chromosome location (bp)	137039470 - 137046203
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000107281 (version 83.38)
Entrez gene	56654
UniProt	Q9NQX5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NQX5
Antibodypedia	NPDC1 antibodies

PROTEIN BROWSER

NPDC1-001	NPDC1-002	NPDC1-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NPDC1-001 ENSP00000360660 ENST00000371601	Q9NQX5 [Direct mapping] Neural proliferation differentiation and control protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	325 aa 34.5 kDa	Yes	1
NPDC1-002 ENSP00000360659 ENST00000371600	Q5SPY9 [Direct mapping] Neural proliferation differentiation and control protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	403 aa 42.8 kDa	No	1
NPDC1-006 ENSP00000481901 ENST00000472668	A0A087WYK7 [Direct mapping] Neural proliferation differentiation and control protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		28 aa 3.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.