Fields »
ABOUT
HELP
BLOG
APBA1

GENERAL INFORMATION

Gene name

 APBA1

Gene description

 Amyloid beta (A4) precursor protein-binding, family A, member 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (cerebral cortex)
GTEx:Expressed in all
FANTOM5:Tissue enhanced (cerebellum)

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex)
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin05101520TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin051015202530RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebellum)
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina01020304050Tags Per Million

GENE INFORMATION

Gene name

 APBA1 (HGNC Symbol)

Synonyms

 D9S411E, MINT1, X11

Description

 Amyloid beta (A4) precursor protein-binding, family A, member 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. [provided by RefSeq, Jul 2008]

Chromosome

 9

Cytoband

 q21.12

Chromosome location (bp)

 69427530 - 69672306

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000107282 (version 83.38)

Entrez gene

 320

UniProt

 Q02410 (UniProt - Evidence at protein level)

neXtProt

 NX_Q02410

Antibodypedia

 APBA1 antibodies

PROTEIN BROWSER
APBA1-001
APBA1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
APBA1-001
ENSP00000265381
ENST00000265381
Q02410 [Direct mapping]
Amyloid beta A4 precursor protein-binding family A member 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001540 [beta-amyloid binding]
GO:0001701 [in utero embryonic development]
GO:0005515 [protein binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005634 [nucleus]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006461 [protein complex assembly]
GO:0006886 [intracellular protein transport]
GO:0007155 [cell adhesion]
GO:0007268 [synaptic transmission]
GO:0007269 [neurotransmitter secretion]
GO:0007399 [nervous system development]
GO:0007626 [locomotory behavior]
GO:0008021 [synaptic vesicle]
GO:0008088 [axon cargo transport]
GO:0010468 [regulation of gene expression]
GO:0014047 [glutamate secretion]
GO:0014051 [gamma-aminobutyric acid secretion]
GO:0016020 [membrane]
GO:0030165 [PDZ domain binding]
GO:0032403 [protein complex binding]
GO:0035264 [multicellular organism growth]
GO:0043234 [protein complex]
GO:0048471 [perinuclear region of cytoplasm]
Show all
 837 aa
92.9 kDa 		No 0
APBA1-002
ENSP00000486435
ENST00000470082
A0A0D9SFA9 [Direct mapping]
Amyloid beta A4 precursor protein-binding family A member 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001540 [beta-amyloid binding]
GO:0005515 [protein binding]
GO:0006461 [protein complex assembly]
GO:0007268 [synaptic transmission]
GO:0008021 [synaptic vesicle]
Show all
 122 aa
13.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.