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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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SH3GL2
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    TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

SH3GL2

Gene description

SH3-domain GRB2-like 2

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Tissue enhanced (glioma)
HPA (cell line):Cell line enhanced (HeLa, RT4, SCLC-21H)
HPA (normal tissue):Tissue enriched (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in CNS.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 3 antibodies.
HPA026685 , HPA063573 , CAB010056
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PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Tissue enhanced (glioma)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA026685
HPA063573
CAB010056

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cancer cells were in general negative. A few cases of gliomas showed distinct immunoreactivity in neuropil.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cancer tissues were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cases of gliomas and cervical squamous cells carcinomas showed moderate immunoreactivity. Cancer cells in general were weakly stained or negative.

GENE INFORMATION

Gene name

SH3GL2 (HGNC Symbol)

Synonyms

CNSA2, EEN-B1, SH3D2A, SH3P4

Description

SH3-domain GRB2-like 2 (HGNC Symbol)

Entrez gene summary

Chromosome

9

Cytoband

p22.2

Chromosome location (bp)

17579082 - 17797129

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000107295 (version 83.38)

Entrez gene

6456

UniProt

Q99962 (UniProt - Evidence at protein level)

neXtProt

NX_Q99962

Antibodypedia

SH3GL2 antibodies

PROTEIN BROWSER

SH3GL2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SH3GL2-001
ENSP00000369981
ENST00000380607
Q99962 [Direct mapping]
Endophilin-A1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0002090 [regulation of receptor internalization]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007411 [axon guidance]
GO:0007417 [central nervous system development]
GO:0008289 [lipid binding]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030669 [clathrin-coated endocytic vesicle membrane]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0042802 [identical protein binding]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048488 [synaptic vesicle endocytosis]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
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352 aa
40 kDa
No 0

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