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Gene name

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Subclass

Chromosome

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In atlas

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Reliability

Reliability

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Method

Validation

Method

Validation

Method

Validation

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Searches

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Cell line

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Cancer

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Detectable

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Detectable

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ABCA2
  • TISSUE

  • CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

ABCA2

Gene description

ATP-binding cassette, sub-family A (ABC1), member 2

Protein class

Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

Intracellular,Membrane

Number of transcripts

6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enriched (cerebral cortex)
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Ubiquitous cytoplasmic and nuclear expression.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Reliability score

Approved based on 1 antibody.
HPA042886
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

ABCA2 (HGNC Symbol)

Synonyms

ABC2

Description

ATP-binding cassette, sub-family A (ABC1), member 2 (HGNC Symbol)

Entrez gene summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is highly expressed in brain tissue and may play a role in macrophage lipid metabolism and neural development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

9

Cytoband

q34.3

Chromosome location (bp)

137007227 - 137028922

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000107331 (version 83.38)

Entrez gene

20

UniProt

Q9BZC7 (UniProt - Evidence at protein level)

neXtProt

NX_Q9BZC7

Antibodypedia

ABCA2 antibodies

PROTEIN BROWSER

ABCA2-002
ABCA2-022
ABCA2-024
ABCA2-201
ABCA2-202
ABCA2-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ABCA2-002
ENSP00000344155
ENST00000341511
Q9BZC7 [Direct mapping]
ATP-binding cassette sub-family A member 2
Show all
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0005524 [ATP binding]
GO:0005764 [lysosome]
GO:0005765 [lysosomal membrane]
GO:0005768 [endosome]
GO:0005815 [microtubule organizing center]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006629 [lipid metabolic process]
GO:0006810 [transport]
GO:0006869 [lipid transport]
GO:0010008 [endosome membrane]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016887 [ATPase activity]
GO:0032383 [regulation of intracellular cholesterol transport]
GO:0042493 [response to drug]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0042632 [cholesterol homeostasis]
GO:0043190 [ATP-binding cassette (ABC) transporter complex]
GO:0048545 [response to steroid hormone]
GO:0055085 [transmembrane transport]
Show all
2436 aa
269.9 kDa
No >9
ABCA2-022
ENSP00000420360
ENST00000490486
H0Y8E3 [Direct mapping]
ATP-binding cassette sub-family A member 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006869 [lipid transport]
GO:0016021 [integral component of membrane]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0055085 [transmembrane transport]
Show all
195 aa
21.9 kDa
No 0
ABCA2-024
ENSP00000485459
ENST00000625103
A0A096LP90 [Direct mapping]
ATP-binding cassette sub-family A member 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006869 [lipid transport]
GO:0016021 [integral component of membrane]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0055085 [transmembrane transport]
Show all
122 aa
13.6 kDa
No 1
ABCA2-201
ENSP00000265662
ENST00000265662
J3QSS3 [Direct mapping]
ATP-binding cassette sub-family A member 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0006869 [lipid transport]
GO:0008152 [metabolic process]
GO:0016021 [integral component of membrane]
GO:0016887 [ATPase activity]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0055085 [transmembrane transport]
Show all
2436 aa
269.9 kDa
No >9
ABCA2-202
ENSP00000360666
ENST00000371605
Q9BZC7 [Direct mapping]
ATP-binding cassette sub-family A member 2
Show all
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0005524 [ATP binding]
GO:0005764 [lysosome]
GO:0005765 [lysosomal membrane]
GO:0005768 [endosome]
GO:0005815 [microtubule organizing center]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006629 [lipid metabolic process]
GO:0006810 [transport]
GO:0006869 [lipid transport]
GO:0010008 [endosome membrane]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016887 [ATPase activity]
GO:0032383 [regulation of intracellular cholesterol transport]
GO:0042493 [response to drug]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0042632 [cholesterol homeostasis]
GO:0043190 [ATP-binding cassette (ABC) transporter complex]
GO:0048545 [response to steroid hormone]
GO:0055085 [transmembrane transport]
Show all
2435 aa
269.8 kDa
No >9
ABCA2-203
ENSP00000481105
ENST00000614293
A0A087WXK5 [Direct mapping]
ATP-binding cassette sub-family A member 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0006869 [lipid transport]
GO:0008152 [metabolic process]
GO:0016021 [integral component of membrane]
GO:0016887 [ATPase activity]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0055085 [transmembrane transport]
Show all
2466 aa
273 kDa
No >9

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