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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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DVL1
  • TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

DVL1

Gene description

Dishevelled segment polarity protein 1

Protein class

Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Approved based on 1 antibody.
CAB011538
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PROGNOSTIC SUMMARY

Prognostic marker in testis cancer (favourable).
Testis cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

CAB011538

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cancer cells showed moderate to strong cytoplasmic positivity often with a granular pattern. Several cases of renal carcinomas and malignant gliomas displayed were negative.

GENE INFORMATION

Gene name

DVL1

Synonyms

Description

Dishevelled segment polarity protein 1 (HGNC Symbol)

Entrez gene summary

DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development. [provided by RefSeq, Jul 2008]

Chromosome

1

Cytoband

p36.33

Chromosome location (bp)

1335276 - 1349350

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000107404 (version 83.38)

Entrez gene

1855

UniProt

O14640 (UniProt - Evidence at protein level)

neXtProt

NX_O14640

Antibodypedia

DVL1 antibodies

PROTEIN BROWSER

DVL1-001
DVL1-004
DVL1-006
DVL1-009
DVL1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DVL1-001
ENSP00000368169
ENST00000378891
O14640 [Direct mapping]
Segment polarity protein dishevelled homolog DVL-1
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001505 [regulation of neurotransmitter levels]
GO:0001932 [regulation of protein phosphorylation]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0005109 [frizzled binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006469 [negative regulation of protein kinase activity]
GO:0007269 [neurotransmitter secretion]
GO:0007409 [axonogenesis]
GO:0007411 [axon guidance]
GO:0007528 [neuromuscular junction development]
GO:0010976 [positive regulation of neuron projection development]
GO:0015630 [microtubule cytoskeleton]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016328 [lateral plasma membrane]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0021915 [neural tube development]
GO:0022007 [convergent extension involved in neural plate elongation]
GO:0030136 [clathrin-coated vesicle]
GO:0030177 [positive regulation of Wnt signaling pathway]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030426 [growth cone]
GO:0031122 [cytoplasmic microtubule organization]
GO:0031410 [cytoplasmic vesicle]
GO:0032091 [negative regulation of protein binding]
GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0034504 [protein localization to nucleus]
GO:0035176 [social behavior]
GO:0035372 [protein localization to microtubule]
GO:0035556 [intracellular signal transduction]
GO:0042802 [identical protein binding]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043113 [receptor clustering]
GO:0045202 [synapse]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0048365 [Rac GTPase binding]
GO:0048668 [collateral sprouting]
GO:0048675 [axon extension]
GO:0048813 [dendrite morphogenesis]
GO:0050808 [synapse organization]
GO:0050821 [protein stabilization]
GO:0060029 [convergent extension involved in organogenesis]
GO:0060070 [canonical Wnt signaling pathway]
GO:0060071 [Wnt signaling pathway, planar cell polarity pathway]
GO:0060134 [prepulse inhibition]
GO:0071340 [skeletal muscle acetylcholine-gated channel clustering]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090103 [cochlea morphogenesis]
GO:0090179 [planar cell polarity pathway involved in neural tube closure]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:1903827 [regulation of cellular protein localization]
Show all
670 aa
72.9 kDa
No 0
DVL1-004
ENSP00000368166
ENST00000378888
O14640 [Direct mapping]
Segment polarity protein dishevelled homolog DVL-1
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001505 [regulation of neurotransmitter levels]
GO:0005109 [frizzled binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006469 [negative regulation of protein kinase activity]
GO:0007269 [neurotransmitter secretion]
GO:0007528 [neuromuscular junction development]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016328 [lateral plasma membrane]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0021915 [neural tube development]
GO:0030177 [positive regulation of Wnt signaling pathway]
GO:0030426 [growth cone]
GO:0031410 [cytoplasmic vesicle]
GO:0032091 [negative regulation of protein binding]
GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0034504 [protein localization to nucleus]
GO:0035556 [intracellular signal transduction]
GO:0042802 [identical protein binding]
GO:0043005 [neuron projection]
GO:0043113 [receptor clustering]
GO:0045202 [synapse]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0048813 [dendrite morphogenesis]
GO:0050808 [synapse organization]
GO:0050821 [protein stabilization]
GO:0060070 [canonical Wnt signaling pathway]
GO:0060071 [Wnt signaling pathway, planar cell polarity pathway]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090179 [planar cell polarity pathway involved in neural tube closure]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:1903827 [regulation of cellular protein localization]
Show all
695 aa
75.2 kDa
No 0
DVL1-006
ENSP00000488181
ENST00000631679
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0035556 [intracellular signal transduction]
Show all
251 aa
27.7 kDa
No 0
DVL1-009
ENSP00000488888
ENST00000632445
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0035556 [intracellular signal transduction]
Show all
217 aa
23.3 kDa
No 0
DVL1-201
ENSP00000480077
ENST00000610709
A0A087WWA7 [Direct mapping]
Segment polarity protein dishevelled homolog DVL-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0035556 [intracellular signal transduction]
GO:0090179 [planar cell polarity pathway involved in neural tube closure]
Show all
444 aa
47.7 kDa
No 0

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