Cell atlas - DNTT - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

DNTT

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm

Human cell
	Cytosol
	Nucleoplasm

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	DNTT
Gene description	DNA nucleotidylexotransferase
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the cytosol.
RNA cell category	Group enriched (REH, MOLT-4)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved)
Additional location	In addition localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA044194
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (REH, MOLT-4) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the cytosol.

Main location

Nucleoplasm (approved)

Additional location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA044194	A-431	Nucleoplasm
	HPA044194	U-2 OS	Nucleoplasm
	HPA044194	U-2 OS	Cytosol
	HPA044194	U-251 MG	Nucleoplasm

GENE INFORMATION
Gene name	DNTT (HGNC Symbol)
Synonyms	TDT
Description	DNA nucleotidylexotransferase (HGNC Symbol)
Entrez gene summary	This gene is a member of the DNA polymerase type-X family and encodes a template-independent DNA polymerase that catalyzes the addition of deoxynucleotides to the 3'-hydroxyl terminus of oligonucleotide primers. In vivo, the encoded protein is expressed in a restricted population of normal and malignant pre-B and pre-T lymphocytes during early differentiation, where it generates antigen receptor diversity by synthesizing non-germ line elements (N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor gene segments. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jul 2008]
Chromosome	10
Cytoband	q24.1
Chromosome location (bp)	96304396 - 96338564
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000107447 (version 83.38)
Entrez gene	1791
UniProt	P04053 (UniProt - Evidence at protein level)
neXtProt	NX_P04053
Antibodypedia	DNTT antibodies

PROTEIN BROWSER

DNTT-001	DNTT-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DNTT-001 ENSP00000360216 ENST00000371174	P04053 [Direct mapping] DNA nucleotidylexotransferase Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003887 [DNA-directed DNA polymerase activity] GO:0003912 [DNA nucleotidylexotransferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006259 [DNA metabolic process] GO:0006304 [DNA modification] GO:0016779 [nucleotidyltransferase activity] GO:0034061 [DNA polymerase activity] GO:0046872 [metal ion binding] GO:0071897 [DNA biosynthetic process] Show all	509 aa 58.5 kDa	No	0
DNTT-002 ENSP00000486733 ENST00000630152	P04053 [Direct mapping] DNA nucleotidylexotransferase Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003887 [DNA-directed DNA polymerase activity] GO:0003912 [DNA nucleotidylexotransferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006259 [DNA metabolic process] GO:0006304 [DNA modification] GO:0016779 [nucleotidyltransferase activity] GO:0034061 [DNA polymerase activity] GO:0046872 [metal ion binding] GO:0071897 [DNA biosynthetic process] Show all	508 aa 58.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.