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PKD2L1

GENERAL INFORMATION

Gene name

 PKD2L1

Gene description

 Polycystic kidney disease 2-like 1

Protein class

 Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Transporters
Voltage-gated ion channels

Predicted localization

 Intracellular,Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (spleen)
GTEx:Tissue enhanced (cerebral cortex, spleen, testis)
FANTOM5:Not detected

Protein evidence

 Evidence at protein level

Protein expression

 Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification. Antibody staining not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
CAB022621
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (spleen)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex, spleen, testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Not detected

GENE INFORMATION

Gene name

 PKD2L1 (HGNC Symbol)

Synonyms

 PCL, PKD2L, PKDL, TRPP3

Description

 Polycystic kidney disease 2-like 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the polycystin protein family. The encoded protein contains multiple transmembrane domains, and cytoplasmic N- and C-termini. The protein may be an integral membrane protein involved in cell-cell/matrix interactions. This protein functions as a calcium-regulated nonselective cation channel. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Chromosome

 10

Cytoband

 q24.31

Chromosome location (bp)

 100288154 - 100330486

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000107593 (version 83.38)

Entrez gene

 9033

UniProt

 Q9P0L9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9P0L9

Antibodypedia

 PKD2L1 antibodies

PROTEIN BROWSER
PKD2L1-001
PKD2L1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PKD2L1-001
ENSP00000325296
ENST00000318222
Q9P0L9 [Direct mapping]
Polycystic kidney disease 2-like 1 protein
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Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Transient Receptor Potential Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
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GO:0001581 [detection of chemical stimulus involved in sensory perception of sour taste]
GO:0005227 [calcium activated cation channel activity]
GO:0005261 [cation channel activity]
GO:0005262 [calcium channel activity]
GO:0005272 [sodium channel activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005886 [plasma membrane]
GO:0006812 [cation transport]
GO:0007224 [smoothened signaling pathway]
GO:0008092 [cytoskeletal protein binding]
GO:0008324 [cation transmembrane transporter activity]
GO:0009986 [cell surface]
GO:0015269 [calcium-activated potassium channel activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0031513 [nonmotile primary cilium]
GO:0033040 [sour taste receptor activity]
GO:0034703 [cation channel complex]
GO:0034704 [calcium channel complex]
GO:0035725 [sodium ion transmembrane transport]
GO:0042802 [identical protein binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043235 [receptor complex]
GO:0050915 [sensory perception of sour taste]
GO:0050982 [detection of mechanical stimulus]
GO:0051371 [muscle alpha-actinin binding]
GO:0051393 [alpha-actinin binding]
GO:0060170 [ciliary membrane]
GO:0070207 [protein homotrimerization]
GO:0070588 [calcium ion transmembrane transport]
GO:0071468 [cellular response to acidic pH]
GO:0071805 [potassium ion transmembrane transport]
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 805 aa
92 kDa 		No 6
PKD2L1-002
ENSP00000434019
ENST00000465680
H0YDN7 [Direct mapping]
Polycystic kidney disease 2-like 1 protein
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Predicted intracellular proteins
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GO:0050982 [detection of mechanical stimulus]
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 62 aa
7.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.