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CUBN

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GENERAL INFORMATION

Gene name

 CUBN

Gene description

 Cubilin (intrinsic factor-cobalamin receptor)

Protein class

 Disease related genes
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (AN3-CA, WM-115)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (AN3-CA, WM-115)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 CUBN (HGNC Symbol)

Synonyms

 gp280, IFCR, MGA1

Description

 Cubilin (intrinsic factor-cobalamin receptor) (HGNC Symbol)

Entrez gene summary

 Cubilin (CUBN) acts as a receptor for intrinsic factor-vitamin B12 complexes. The role of receptor is supported by the presence of 27 CUB domains. Cubulin is located within the epithelium of intestine and kidney. Mutations in CUBN may play a role in autosomal recessive megaloblastic anemia. [provided by RefSeq, Jul 2008]

Chromosome

 10

Cytoband

 p13

Chromosome location (bp)

 16823964 - 17129831

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000107611 (version 83.38)

Entrez gene

 8029

UniProt

 O60494 (UniProt - Evidence at protein level)

neXtProt

 NX_O60494

Antibodypedia

 CUBN antibodies

PROTEIN BROWSER
CUBN-001
CUBN-002
CUBN-003
CUBN-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CUBN-001
ENSP00000367064
ENST00000377833
O60494 [Direct mapping]
Cubilin
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001894 [tissue homeostasis]
GO:0004872 [receptor activity]
GO:0005215 [transporter activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005765 [lysosomal membrane]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005903 [brush border]
GO:0005905 [coated pit]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0006898 [receptor-mediated endocytosis]
GO:0008202 [steroid metabolic process]
GO:0008203 [cholesterol metabolic process]
GO:0009235 [cobalamin metabolic process]
GO:0010008 [endosome membrane]
GO:0015889 [cobalamin transport]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0030139 [endocytic vesicle]
GO:0031232 [extrinsic component of external side of plasma membrane]
GO:0031419 [cobalamin binding]
GO:0031526 [brush border membrane]
GO:0042157 [lipoprotein metabolic process]
GO:0042359 [vitamin D metabolic process]
GO:0042803 [protein homodimerization activity]
GO:0042953 [lipoprotein transport]
GO:0043202 [lysosomal lumen]
GO:0044281 [small molecule metabolic process]
GO:0045177 [apical part of cell]
GO:0070062 [extracellular exosome]
Show all
 3623 aa
398.7 kDa 		Yes 0
CUBN-002
ENSP00000391830
ENST00000438254
Q5JQ33 [Direct mapping]
Cubilin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 88 aa
9.7 kDa 		No 0
CUBN-003
ENSP00000367054
ENST00000377823
B0YIZ6 [Direct mapping]
Cubilin; Cubilin variant 3
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
Show all
 170 aa
19.2 kDa 		Yes 0
CUBN-004
ENSP00000415970
ENST00000433666
H7C480 [Direct mapping]
Cubilin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
Show all
 105 aa
11.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.