Fields »
ABOUT
HELP
BLOG
DDX50

GENERAL INFORMATION

Gene name

 DDX50

Gene description

 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Mainly nucleolar expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA037388 , HPA058196
SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Ovarian cancer

STAINING SUMMARY
HPA037388
HPA058196

GENE INFORMATION

Gene name

 DDX50 (HGNC Symbol)

Synonyms

 GU2, GUB, MGC3199, RH-II/GuB

Description

 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 (HGNC Symbol)

Entrez gene summary

 DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box enzyme that may be involved in ribosomal RNA synthesis or processing. This gene and DDX21, also called RH-II/GuA, have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. This gene has pseudogenes on chromosomes 2, 3 and 4. Alternative splicing of this gene generates multiple transcript variants, but the full length nature of all the other variants but one has not been defined. [provided by RefSeq, Jul 2008]

Chromosome

 10

Cytoband

 q22.1

Chromosome location (bp)

 68901278 - 68946847

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000107625 (version 83.38)

Entrez gene

 79009

UniProt

 Q9BQ39 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BQ39

Antibodypedia

 DDX50 antibodies

PROTEIN BROWSER
DDX50-001
DDX50-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DDX50-001
ENSP00000362687
ENST00000373585
Q9BQ39 [Direct mapping]
ATP-dependent RNA helicase DDX50
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0004386 [helicase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005886 [plasma membrane]
GO:0010501 [RNA secondary structure unwinding]
GO:0016020 [membrane]
GO:0044822 [poly(A) RNA binding]
Show all
 737 aa
82.6 kDa 		No 0
DDX50-201
ENSP00000479336
ENST00000610822
A0A087WVC1 [Direct mapping]
ATP-dependent RNA helicase DDX50
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0004386 [helicase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0010501 [RNA secondary structure unwinding]
Show all
 730 aa
82.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.