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MAPK8

GENERAL INFORMATION

Gene name

 MAPK8

Gene description

 Mitogen-activated protein kinase 8

Protein class

 Cancer-related genes
Enzymes
Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 10
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Mainly cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
CAB004463 , CAB069396
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 MAPK8 (HGNC Symbol)

Synonyms

 JNK, JNK1, PRKM8, SAPK1

Description

 Mitogen-activated protein kinase 8 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jun 2013]

Chromosome

 10

Cytoband

 q11.22

Chromosome location (bp)

 48306639 - 48439360

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000107643 (version 83.38)

Entrez gene

 5599

UniProt

 P45983 (UniProt - Evidence at protein level)

neXtProt

 NX_P45983

Antibodypedia

 MAPK8 antibodies

PROTEIN BROWSER
MAPK8-004
MAPK8-006
MAPK8-008
MAPK8-009
MAPK8-011
MAPK8-012
MAPK8-013
MAPK8-014
MAPK8-201
MAPK8-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MAPK8-004
ENSP00000393223
ENST00000429041
C9JWQ4 [Direct mapping]
Mitogen-activated protein kinase 8
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0004672 [protein kinase activity]
GO:0004707 [MAP kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
Show all
 97 aa
11.1 kDa 		No 0
MAPK8-006
ENSP00000363304
ENST00000374189
P45983 [Direct mapping]
Mitogen-activated protein kinase 8
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004705 [JUN kinase activity]
GO:0004707 [MAP kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0006950 [response to stress]
GO:0007254 [JNK cascade]
GO:0007258 [JUN phosphorylation]
GO:0009411 [response to UV]
GO:0010628 [positive regulation of gene expression]
GO:0012501 [programmed cell death]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0019899 [enzyme binding]
GO:0031063 [regulation of histone deacetylation]
GO:0031281 [positive regulation of cyclase activity]
GO:0032091 [negative regulation of protein binding]
GO:0032880 [regulation of protein localization]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035033 [histone deacetylase regulator activity]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0042752 [regulation of circadian rhythm]
GO:0042826 [histone deacetylase binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0045087 [innate immune response]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048511 [rhythmic process]
GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity]
GO:0051247 [positive regulation of protein metabolic process]
GO:0051403 [stress-activated MAPK cascade]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071260 [cellular response to mechanical stimulus]
GO:0090045 [positive regulation of deacetylase activity]
GO:0097190 [apoptotic signaling pathway]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
Show all
 427 aa
48.3 kDa 		No 0
MAPK8-008
ENSP00000387936
ENST00000432379
C9J762 [Direct mapping]
Mitogen-activated protein kinase 8
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0004672 [protein kinase activity]
GO:0004707 [MAP kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
Show all
 142 aa
16.4 kDa 		No 0
MAPK8-009
ENSP00000397729
ENST00000426557
C9J762 [Direct mapping]
Mitogen-activated protein kinase 8
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0004672 [protein kinase activity]
GO:0004707 [MAP kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
Show all
 142 aa
16.4 kDa 		No 0
MAPK8-011
ENSP00000363297
ENST00000374182
P45983 [Direct mapping]
Mitogen-activated protein kinase 8
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004705 [JUN kinase activity]
GO:0004707 [MAP kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0006950 [response to stress]
GO:0007254 [JNK cascade]
GO:0007258 [JUN phosphorylation]
GO:0009411 [response to UV]
GO:0010628 [positive regulation of gene expression]
GO:0012501 [programmed cell death]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0019899 [enzyme binding]
GO:0031063 [regulation of histone deacetylation]
GO:0031281 [positive regulation of cyclase activity]
GO:0032091 [negative regulation of protein binding]
GO:0032880 [regulation of protein localization]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035033 [histone deacetylase regulator activity]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0042752 [regulation of circadian rhythm]
GO:0042826 [histone deacetylase binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0045087 [innate immune response]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048511 [rhythmic process]
GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity]
GO:0051247 [positive regulation of protein metabolic process]
GO:0051403 [stress-activated MAPK cascade]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071260 [cellular response to mechanical stimulus]
GO:0090045 [positive regulation of deacetylase activity]
GO:0097190 [apoptotic signaling pathway]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
Show all
 384 aa
44.2 kDa 		No 0
MAPK8-012
ENSP00000363294
ENST00000374179
P45983 [Direct mapping]
Mitogen-activated protein kinase 8
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004705 [JUN kinase activity]
GO:0004707 [MAP kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0006950 [response to stress]
GO:0007254 [JNK cascade]
GO:0007258 [JUN phosphorylation]
GO:0009411 [response to UV]
GO:0010628 [positive regulation of gene expression]
GO:0012501 [programmed cell death]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0019899 [enzyme binding]
GO:0031063 [regulation of histone deacetylation]
GO:0031281 [positive regulation of cyclase activity]
GO:0032091 [negative regulation of protein binding]
GO:0032880 [regulation of protein localization]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035033 [histone deacetylase regulator activity]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0042752 [regulation of circadian rhythm]
GO:0042826 [histone deacetylase binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0045087 [innate immune response]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048511 [rhythmic process]
GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity]
GO:0051247 [positive regulation of protein metabolic process]
GO:0051403 [stress-activated MAPK cascade]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071260 [cellular response to mechanical stimulus]
GO:0090045 [positive regulation of deacetylase activity]
GO:0097190 [apoptotic signaling pathway]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
Show all
 384 aa
44 kDa 		No 0
MAPK8-013
ENSP00000363289
ENST00000374174
A6NF29 [Direct mapping]
Mitogen-activated protein kinase 8
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0004672 [protein kinase activity]
GO:0004707 [MAP kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
Show all
 218 aa
24.9 kDa 		No 0
MAPK8-014
ENSP00000363291
ENST00000374176
P45983 [Direct mapping]
Mitogen-activated protein kinase 8
A1L4K2 [Target identity:100%; Query identity:100%]
Mitogen-activated protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004705 [JUN kinase activity]
GO:0004707 [MAP kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0006950 [response to stress]
GO:0007254 [JNK cascade]
GO:0007258 [JUN phosphorylation]
GO:0009411 [response to UV]
GO:0010628 [positive regulation of gene expression]
GO:0012501 [programmed cell death]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0019899 [enzyme binding]
GO:0031063 [regulation of histone deacetylation]
GO:0031281 [positive regulation of cyclase activity]
GO:0032091 [negative regulation of protein binding]
GO:0032880 [regulation of protein localization]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035033 [histone deacetylase regulator activity]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0042752 [regulation of circadian rhythm]
GO:0042826 [histone deacetylase binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0045087 [innate immune response]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048511 [rhythmic process]
GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity]
GO:0051247 [positive regulation of protein metabolic process]
GO:0051403 [stress-activated MAPK cascade]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071260 [cellular response to mechanical stimulus]
GO:0090045 [positive regulation of deacetylase activity]
GO:0097190 [apoptotic signaling pathway]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
Show all
 427 aa
48.1 kDa 		No 0
MAPK8-201
ENSP00000353483
ENST00000360332
P45983 [Direct mapping]
Mitogen-activated protein kinase 8
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004705 [JUN kinase activity]
GO:0004707 [MAP kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0006950 [response to stress]
GO:0007254 [JNK cascade]
GO:0007258 [JUN phosphorylation]
GO:0009411 [response to UV]
GO:0010628 [positive regulation of gene expression]
GO:0012501 [programmed cell death]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0019899 [enzyme binding]
GO:0031063 [regulation of histone deacetylation]
GO:0031281 [positive regulation of cyclase activity]
GO:0032091 [negative regulation of protein binding]
GO:0032880 [regulation of protein localization]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035033 [histone deacetylase regulator activity]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0042752 [regulation of circadian rhythm]
GO:0042826 [histone deacetylase binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0045087 [innate immune response]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048511 [rhythmic process]
GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity]
GO:0051247 [positive regulation of protein metabolic process]
GO:0051403 [stress-activated MAPK cascade]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071260 [cellular response to mechanical stimulus]
GO:0090045 [positive regulation of deacetylase activity]
GO:0097190 [apoptotic signaling pathway]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
Show all
 308 aa
35.3 kDa 		No 0
MAPK8-202
ENSP00000378974
ENST00000395611
P45983 [Direct mapping]
Mitogen-activated protein kinase 8
A1L4K2 [Target identity:100%; Query identity:100%]
Mitogen-activated protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001503 [ossification]
GO:0002102 [podosome]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004705 [JUN kinase activity]
GO:0004707 [MAP kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0006950 [response to stress]
GO:0007254 [JNK cascade]
GO:0007258 [JUN phosphorylation]
GO:0009411 [response to UV]
GO:0010468 [regulation of gene expression]
GO:0010628 [positive regulation of gene expression]
GO:0012501 [programmed cell death]
GO:0016301 [kinase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0019899 [enzyme binding]
GO:0031063 [regulation of histone deacetylation]
GO:0031281 [positive regulation of cyclase activity]
GO:0032091 [negative regulation of protein binding]
GO:0032880 [regulation of protein localization]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035033 [histone deacetylase regulator activity]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0042752 [regulation of circadian rhythm]
GO:0042826 [histone deacetylase binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0045087 [innate immune response]
GO:0046686 [response to cadmium ion]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048511 [rhythmic process]
GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity]
GO:0051247 [positive regulation of protein metabolic process]
GO:0051403 [stress-activated MAPK cascade]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071732 [cellular response to nitric oxide]
GO:0071803 [positive regulation of podosome assembly]
GO:0090045 [positive regulation of deacetylase activity]
GO:0097190 [apoptotic signaling pathway]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:0097300 [programmed necrotic cell death]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:2000017 [positive regulation of determination of dorsal identity]
GO:2001235 [positive regulation of apoptotic signaling pathway]
Show all
 427 aa
48.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.