Expression of ATE1 in cancer - Summary - The Human Protein Atlas

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ATE1

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ATE1
Gene description	Arginyltransferase 1
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA038444
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA038444

GENE INFORMATION
Gene name	ATE1
Synonyms
Description	Arginyltransferase 1 (HGNC Symbol)
Entrez gene summary	This gene encodes an arginyltransferase, an enzyme that is involved in posttranslational conjugation of arginine to N-terminal aspartate or glutamate residues. Conjugation of arginine to the N-terminal aspartate or glutamate targets proteins for ubiquitin-dependent degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Chromosome	10
Cytoband	q26.13
Chromosome location (bp)	121740421 - 121928801
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000107669 (version 83.38)
Entrez gene	11101
UniProt	O95260 (UniProt - Evidence at protein level)
neXtProt	NX_O95260
Antibodypedia	ATE1 antibodies

PROTEIN BROWSER

ATE1-001	ATE1-002	ATE1-006	ATE1-201	ATE1-202	ATE1-203	ATE1-204

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ATE1-001 ENSP00000358039 ENST00000369043	O95260 [Direct mapping] Arginyl-tRNA--protein transferase 1 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004057 [arginyltransferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0016598 [protein arginylation] Show all	518 aa 59 kDa	No	0
ATE1-002 ENSP00000397787 ENST00000423243	H0Y5C2 [Direct mapping] Arginyl-tRNA--protein transferase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004057 [arginyltransferase activity] GO:0016598 [protein arginylation] Show all	515 aa 58.6 kDa	No	0
ATE1-006 ENSP00000405099 ENST00000455628	Q5SQQ1 [Direct mapping] Arginyl-tRNA--protein transferase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004057 [arginyltransferase activity] GO:0016598 [protein arginylation] Show all	222 aa 24.9 kDa	No	0
ATE1-201 ENSP00000224652 ENST00000224652	O95260 [Direct mapping] Arginyl-tRNA--protein transferase 1 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004057 [arginyltransferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0016598 [protein arginylation] Show all	518 aa 59.1 kDa	No	0
ATE1-202 ENSP00000358036 ENST00000369040	B4E107 [Direct mapping] Arginyl-tRNA--protein transferase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004057 [arginyltransferase activity] GO:0016598 [protein arginylation] Show all	422 aa 47.8 kDa	No	0
ATE1-203 ENSP00000440881 ENST00000540606	F5GXE4 [Direct mapping] Arginyl-tRNA--protein transferase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004057 [arginyltransferase activity] GO:0016598 [protein arginylation] Show all	511 aa 58.1 kDa	No	0
ATE1-204 ENSP00000444852 ENST00000543447	B4DK25 [Direct mapping] Arginyl-tRNA--protein transferase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004057 [arginyltransferase activity] GO:0016598 [protein arginylation] Show all	403 aa 45.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.