Expression of CDH23 in cancer - Summary - The Human Protein Atlas

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CDH23

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CDH23
Gene description	Cadherin-related 23
Protein class	Disease related genes Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	12
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (RT4, SCLC-21H)
HPA (normal tissue):	Tissue enhanced (parathyroid gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Caution, Splice and/or transcript discrepancy exists. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA017232
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (favourable).
Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA017232

GENE INFORMATION
Gene name	CDH23 (HGNC Symbol)
Synonyms	CDHR23, DFNB12, USH1D
Description	Cadherin-related 23 (HGNC Symbol)
Entrez gene summary	This gene is a member of the cadherin superfamily, whose genes encode calcium dependent cell-cell adhesion glycoproteins. The encoded protein is thought to be involved in stereocilia organization and hair bundle formation. The gene is located in a region containing the human deafness loci DFNB12 and USH1D. Usher syndrome 1D and nonsyndromic autosomal recessive deafness DFNB12 are caused by allelic mutations of this cadherin-like gene. Upregulation of this gene may also be associated with breast cancer. Alternative splice variants encoding different isoforms have been described. [provided by RefSeq, May 2013]
Chromosome	10
Cytoband	q22.1
Chromosome location (bp)	71396934 - 71815947
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000107736 (version 83.38)
Entrez gene	64072
UniProt	Q9H251 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H251
Antibodypedia	CDH23 antibodies

PROTEIN BROWSER

CDH23-001	CDH23-002	CDH23-003	CDH23-004	CDH23-005	CDH23-006	CDH23-009	CDH23-201	CDH23-202	CDH23-203	CDH23-204	CDH23-205

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CDH23-001 ENSP00000224721 ENST00000224721	A0A0A0MQS6 [Direct mapping] Cadherin-23 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005509 [calcium ion binding] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	3359 aa 369.9 kDa	Yes	1
CDH23-002 ENSP00000473454 ENST00000461841	R4GN22 [Direct mapping] Cadherin-23 Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005509 [calcium ion binding] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	530 aa 58.6 kDa	Yes	0
CDH23-003 ENSP00000299366 ENST00000299366	G3XCN8 [Direct mapping] Cadherin-23 Q8N5B3 [Target identity:100%; Query identity:100%] CDH23 protein Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005509 [calcium ion binding] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	1061 aa 116.6 kDa	Yes	0
CDH23-004 ENSP00000473539 ENST00000466757	R4GN92 [Direct mapping] Cadherin-23 Show all	Predicted intracellular proteins Show all	GO:0005509 [calcium ion binding] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0016020 [membrane] Show all	954 aa 104.5 kDa	No	0
CDH23-005 ENSP00000480146 ENST00000470494	A0A087WWD9 [Direct mapping] Cadherin-23 Show all	Predicted intracellular proteins Show all	GO:0005509 [calcium ion binding] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0016020 [membrane] Show all	165 aa 18.5 kDa	No	0
CDH23-006 ENSP00000388894 ENST00000442677	B1AVV0 [Direct mapping] Cadherin-23 Show all	Predicted intracellular proteins Show all	GO:0005509 [calcium ion binding] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0016020 [membrane] Show all	803 aa 88 kDa	No	0
CDH23-009 ENSP00000482036 ENST00000616684	A0A087WYR8 [Direct mapping] Cadherin-23 Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005509 [calcium ion binding] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	1381 aa 152.2 kDa	Yes	0
CDH23-201 ENSP00000381768 ENST00000398788	Q9H251 [Direct mapping] Cadherin-23 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Show all	GO:0001917 [photoreceptor inner segment] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006816 [calcium ion transport] GO:0007155 [cell adhesion] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0007601 [visual perception] GO:0007605 [sensory perception of sound] GO:0007626 [locomotory behavior] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016339 [calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0032420 [stereocilium] GO:0032426 [stereocilium bundle tip] GO:0042472 [inner ear morphogenesis] GO:0042491 [auditory receptor cell differentiation] GO:0045202 [synapse] GO:0045494 [photoreceptor cell maintenance] GO:0048563 [post-embryonic organ morphogenesis] GO:0048839 [inner ear development] GO:0050896 [response to stimulus] GO:0050953 [sensory perception of light stimulus] GO:0050957 [equilibrioception] GO:0051480 [cytosolic calcium ion homeostasis] GO:0060088 [auditory receptor cell stereocilium organization] GO:0060091 [kinocilium] GO:0060122 [inner ear receptor stereocilium organization] Show all	1114 aa 123.5 kDa	No	1
CDH23-202 ENSP00000381789 ENST00000398809	A0A0A0MS94 [Direct mapping] Cadherin-23 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005509 [calcium ion binding] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	1380 aa 152.1 kDa	Yes	0
CDH23-203 ENSP00000381822 ENST00000398842	G8JLI8 [Direct mapping] Cadherin-23 Show all	Predicted intracellular proteins Show all	GO:0005509 [calcium ion binding] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	445 aa 49.1 kDa	No	0
CDH23-204 ENSP00000478374 ENST00000619887	Q9H251 [Direct mapping] Cadherin-23 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006816 [calcium ion transport] GO:0007155 [cell adhesion] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0007601 [visual perception] GO:0007605 [sensory perception of sound] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016339 [calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0032420 [stereocilium] GO:0045494 [photoreceptor cell maintenance] GO:0050896 [response to stimulus] GO:0050953 [sensory perception of light stimulus] GO:0050957 [equilibrioception] GO:0051480 [cytosolic calcium ion homeostasis] Show all	1079 aa 119.6 kDa	No	1
CDH23-205 ENSP00000483211 ENST00000622827	A0A087X097 [Direct mapping] Cadherin-23 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005509 [calcium ion binding] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	3354 aa 369.5 kDa	Yes	1

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