Expression of SPOCK2 in cancer - Summary - The Human Protein Atlas

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SPOCK2

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SPOCK2
Gene description	Sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Group enriched (Hep G2, SCLC-21H)
HPA (normal tissue):	Tissue enhanced (cerebral cortex, lung)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression at varying levels in most tissues, most abundant in CNS.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA044605
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PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (favourable), breast cancer (favourable), melanoma (favourable) and ovarian cancer (unfavourable).
Head and neck cancer p<0.001 Breast cancer p<0.001 Melanoma p<0.001 Ovarian cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA044605

GENE INFORMATION
Gene name	SPOCK2 (HGNC Symbol)
Synonyms	KIAA0275, testican-2
Description	Sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein which binds with glycosaminoglycans to form part of the extracellular matrix. The protein contains thyroglobulin type-1, follistatin-like, and calcium-binding domains, and has glycosaminoglycan attachment sites in the acidic C-terminal region. Three alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
Chromosome	10
Cytoband	q22.1
Chromosome location (bp)	72059035 - 72089032
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000107742 (version 83.38)
Entrez gene	9806
UniProt	Q92563 (UniProt - Evidence at protein level)
neXtProt	NX_Q92563
Antibodypedia	SPOCK2 antibodies

PROTEIN BROWSER

SPOCK2-004	SPOCK2-201	SPOCK2-202	SPOCK2-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SPOCK2-004 ENSP00000362201 ENST00000373109	Q92563 [Direct mapping] Testican-2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005539 [glycosaminoglycan binding] GO:0005578 [proteinaceous extracellular matrix] GO:0007165 [signal transduction] GO:0007416 [synapse assembly] GO:0010811 [positive regulation of cell-substrate adhesion] GO:0019800 [peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan] GO:0030198 [extracellular matrix organization] GO:0045595 [regulation of cell differentiation] GO:0050840 [extracellular matrix binding] Show all	424 aa 46.8 kDa	Yes	0
SPOCK2-201 ENSP00000321108 ENST00000317376	Q92563 [Direct mapping] Testican-2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] GO:0007165 [signal transduction] GO:0007416 [synapse assembly] GO:0030198 [extracellular matrix organization] GO:0045595 [regulation of cell differentiation] Show all	424 aa 46.8 kDa	Yes	0
SPOCK2-202 ENSP00000397715 ENST00000412663	Q92563 [Direct mapping] Testican-2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005578 [proteinaceous extracellular matrix] GO:0007165 [signal transduction] GO:0007416 [synapse assembly] GO:0030198 [extracellular matrix organization] GO:0045595 [regulation of cell differentiation] Show all	77 aa 8.3 kDa	Yes	0
SPOCK2-203 ENSP00000439445 ENST00000536168	F5H283 [Direct mapping] Testican-2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] GO:0007165 [signal transduction] Show all	423 aa 46.6 kDa	Yes	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.