Fields »
ABOUT
HELP
BLOG
MINPP1

GENERAL INFORMATION

Gene name

 MINPP1

Gene description

 Multiple inositol-polyphosphate phosphatase 1

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA026859
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA026859

GENE INFORMATION

Gene name

 MINPP1 (HGNC Symbol)

Synonyms

 MIPP

Description

 Multiple inositol-polyphosphate phosphatase 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes multiple inositol polyphosphate phosphatase; an enzyme that removes 3-phosphate from inositol phosphate substrates. It is the only enzyme known to hydrolzye inositol pentakisphosphate and inositol hexakisphosphate. This enzyme also converts 2,3 bisphosphoglycerate (2,3-BPG) to 2-phosphoglycerate; an activity formerly thought to be exclusive to 2,3-BPG synthase/2-phosphatase (BPGM) in the Rapoport-Luebering shunt of the glycolytic pathway.[provided by RefSeq, Sep 2009]

Chromosome

 10

Cytoband

 q23.2

Chromosome location (bp)

 87504875 - 87553460

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000107789 (version 83.38)

Entrez gene

 9562

UniProt

 Q9UNW1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UNW1

Antibodypedia

 MINPP1 antibodies

PROTEIN BROWSER
MINPP1-001
MINPP1-002
MINPP1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MINPP1-001
ENSP00000361064
ENST00000371996
Q9UNW1 [Direct mapping]
Multiple inositol polyphosphate phosphatase 1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Phobius predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001503 [ossification]
GO:0003993 [acid phosphatase activity]
GO:0005783 [endoplasmic reticulum]
GO:0005788 [endoplasmic reticulum lumen]
GO:0006797 [polyphosphate metabolic process]
GO:0008969 [phosphohistidine phosphatase activity]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0030282 [bone mineralization]
GO:0034417 [bisphosphoglycerate 3-phosphatase activity]
GO:0043647 [inositol phosphate metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0052826 [inositol hexakisphosphate 2-phosphatase activity]
GO:0070062 [extracellular exosome]
Show all
 487 aa
55.1 kDa 		Yes 0
MINPP1-002
ENSP00000361062
ENST00000371994
Q9UNW1 [Direct mapping]
Multiple inositol polyphosphate phosphatase 1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   SCAMPI predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001503 [ossification]
GO:0003993 [acid phosphatase activity]
GO:0005783 [endoplasmic reticulum]
GO:0005788 [endoplasmic reticulum lumen]
GO:0006797 [polyphosphate metabolic process]
GO:0008969 [phosphohistidine phosphatase activity]
GO:0016311 [dephosphorylation]
GO:0030282 [bone mineralization]
GO:0034417 [bisphosphoglycerate 3-phosphatase activity]
GO:0043647 [inositol phosphate metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0052826 [inositol hexakisphosphate 2-phosphatase activity]
GO:0070062 [extracellular exosome]
Show all
 312 aa
34.7 kDa 		Yes 0
MINPP1-201
ENSP00000437823
ENST00000536010
Q9UNW1 [Direct mapping]
Multiple inositol polyphosphate phosphatase 1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001503 [ossification]
GO:0003993 [acid phosphatase activity]
GO:0005783 [endoplasmic reticulum]
GO:0005788 [endoplasmic reticulum lumen]
GO:0006797 [polyphosphate metabolic process]
GO:0008969 [phosphohistidine phosphatase activity]
GO:0016311 [dephosphorylation]
GO:0030282 [bone mineralization]
GO:0034417 [bisphosphoglycerate 3-phosphatase activity]
GO:0043647 [inositol phosphate metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0052826 [inositol hexakisphosphate 2-phosphatase activity]
GO:0070062 [extracellular exosome]
Show all
 286 aa
33.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.