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ACTA2

GENERAL INFORMATION

Gene name

 ACTA2

Gene description

 Actin, alpha 2, smooth muscle, aorta

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (ASC TERT1)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Selective expression in smooth muscle, stromal and myoepithelial cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 4 antibodies.
HPA041264 , HPA041271 , CAB000002 , CAB013531
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA041264
HPA041271
CAB000002
CAB013531

GENE INFORMATION

Gene name

 ACTA2 (HGNC Symbol)

Synonyms

 ACTSA

Description

 Actin, alpha 2, smooth muscle, aorta (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Defects in this gene cause aortic aneurysm familial thoracic type 6. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2008]

Chromosome

 10

Cytoband

 q23.31

Chromosome location (bp)

 88935074 - 88991390

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000107796 (version 83.38)

Entrez gene

 59

UniProt

 P62736 (UniProt - Evidence at protein level)

neXtProt

 NX_P62736

Antibodypedia

 ACTA2 antibodies

PROTEIN BROWSER
ACTA2-001
ACTA2-002
ACTA2-003
ACTA2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ACTA2-001
ENSP00000224784
ENST00000224784
P62736 [Direct mapping]
Actin, aortic smooth muscle
D2JYH4 [Target identity:100%; Query identity:100%]
Actin, alpha 2, smooth muscle, aorta; Actin, alpha 2, smooth muscle, aorta, isoform CRA_a
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Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006936 [muscle contraction]
GO:0009615 [response to virus]
GO:0010628 [positive regulation of gene expression]
GO:0019901 [protein kinase binding]
GO:0030027 [lamellipodium]
GO:0030175 [filopodium]
GO:0043234 [protein complex]
GO:0044297 [cell body]
GO:0070062 [extracellular exosome]
GO:0072144 [glomerular mesangial cell development]
GO:0090131 [mesenchyme migration]
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 377 aa
42 kDa 		No 0
ACTA2-002
ENSP00000396730
ENST00000415557
F6QUT6 [Direct mapping]
Actin, aortic smooth muscle
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 151 aa
16.8 kDa 		No 0
ACTA2-003
ENSP00000398239
ENST00000458159
F6UVQ4 [Direct mapping]
Actin, aortic smooth muscle
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 151 aa
16.8 kDa 		No 0
ACTA2-201
ENSP00000402373
ENST00000458208
P62736 [Direct mapping]
Actin, aortic smooth muscle
D2JYH4 [Target identity:100%; Query identity:100%]
Actin, alpha 2, smooth muscle, aorta; Actin, alpha 2, smooth muscle, aorta, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0006936 [muscle contraction]
GO:0008217 [regulation of blood pressure]
GO:0009615 [response to virus]
GO:0010628 [positive regulation of gene expression]
GO:0014829 [vascular smooth muscle contraction]
GO:0019901 [protein kinase binding]
GO:0030027 [lamellipodium]
GO:0030175 [filopodium]
GO:0030485 [smooth muscle contractile fiber]
GO:0043234 [protein complex]
GO:0044297 [cell body]
GO:0070062 [extracellular exosome]
GO:0072144 [glomerular mesangial cell development]
GO:0090131 [mesenchyme migration]
Show all
 377 aa
42 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.