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TLX1

GENERAL INFORMATION

Gene name

 TLX1

Gene description

 T-cell leukemia homeobox 1

Protein class

 Cancer-related genes
Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (K-562, SCLC-21H, SH-SY5Y)
HPA (normal tissue):Tissue enriched (spleen)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in colorectal cancer (unfavourable).
Colorectal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 TLX1 (HGNC Symbol)

Synonyms

 HOX11, TCL3

Description

 T-cell leukemia homeobox 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a nuclear transcription factor that belongs to the NK-linked or NK-like (NKL) subfamily of homeobox genes. The encoded protein is required for normal development of the spleen during embryogenesis. This protein is also involved in specification of neuronal cell fates. Ectopic expression of this gene due to chromosomal translocations is associated with certain T-cell acute lymphoblastic leukemias. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]

Chromosome

 10

Cytoband

 q24.31

Chromosome location (bp)

 101130505 - 101137789

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000107807 (version 83.38)

Entrez gene

 3195

UniProt

 P31314 (UniProt - Evidence at protein level)

neXtProt

 NX_P31314

Antibodypedia

 TLX1 antibodies

PROTEIN BROWSER
TLX1-001
TLX1-002
TLX1-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TLX1-001
ENSP00000359215
ENST00000370196
P31314 [Direct mapping]
T-cell leukemia homeobox protein 1
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
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GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007417 [central nervous system development]
GO:0008284 [positive regulation of cell proliferation]
GO:0030182 [neuron differentiation]
GO:0043565 [sequence-specific DNA binding]
GO:0045165 [cell fate commitment]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0048536 [spleen development]
GO:0048645 [organ formation]
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 330 aa
34.4 kDa 		No 0
TLX1-002
ENSP00000434358
ENST00000463716
G3V1B7 [Direct mapping]
T-cell leukemia homeobox protein 1
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Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
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 156 aa
15.1 kDa 		No 0
TLX1-003
ENSP00000434914
ENST00000467928
P31314 [Direct mapping]
T-cell leukemia homeobox protein 1
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Show all
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0043565 [sequence-specific DNA binding]
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 257 aa
26.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.