Expression of NPM3 in cancer - Summary - The Human Protein Atlas

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NPM3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NPM3
Gene description	Nucleophosmin/nucleoplasmin 3
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Mainly nuclear or nucleolar expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA036295 , HPA036296
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PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (unfavourable).
Head and neck cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA036295	HPA036296

GENE INFORMATION
Gene name	NPM3
Synonyms
Description	Nucleophosmin/nucleoplasmin 3 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is related to the nuclear chaperone phosphoproteins, nucleoplasmin and nucleophosmin. This protein is strongly expressed in diverse cell types where it localizes primarily to the nucleus. Based on its similarity to nucleoplasmin and nucleophosmin, this protein likely functions as a molecular chaperone in the cell nucleus. [provided by RefSeq, Oct 2008]
Chromosome	10
Cytoband	q24.32
Chromosome location (bp)	101781325 - 101783413
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000107833 (version 83.38)
Entrez gene	10360
UniProt	O75607 (UniProt - Evidence at protein level)
neXtProt	NX_O75607
Antibodypedia	NPM3 antibodies

PROTEIN BROWSER

NPM3-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NPM3-001 ENSP00000359128 ENST00000370110	O75607 [Direct mapping] Nucleoplasmin-3 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005730 [nucleolus] GO:0006364 [rRNA processing] GO:0009303 [rRNA transcription] GO:0044822 [poly(A) RNA binding] Show all	178 aa 19.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.