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ARHGAP21

GENERAL INFORMATION

Gene name

 ARHGAP21

Gene description

 Rho GTPase activating protein 21

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Mainly cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA036610
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA036610

GENE INFORMATION

Gene name

 ARHGAP21 (HGNC Symbol)

Synonyms

 ARHGAP10, KIAA1424

Description

 Rho GTPase activating protein 21 (HGNC Symbol)

Entrez gene summary

 ARHGAP21 functions preferentially as a GTPase-activating protein (GAP) for CDC42 (MIM 116952) and regulates the ARP2/3 complex (MIM 604221) and F-actin dynamics at the Golgi through control of CDC42 activity (Dubois et al., 2005 [PubMed 15793564]).[supplied by OMIM, Mar 2008]

Chromosome

 10

Cytoband

 p12.1

Chromosome location (bp)

 24583609 - 24723668

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000107863 (version 83.38)

Entrez gene

 57584

UniProt

 Q5T5U3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q5T5U3

Antibodypedia

 ARHGAP21 antibodies

PROTEIN BROWSER
ARHGAP21-001
ARHGAP21-003
ARHGAP21-005
ARHGAP21-007
ARHGAP21-010
ARHGAP21-012
ARHGAP21-201
ARHGAP21-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARHGAP21-001
ENSP00000379709
ENST00000396432
Q5T5U3 [Direct mapping]
Rho GTPase-activating protein 21
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000139 [Golgi membrane]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005794 [Golgi apparatus]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0007030 [Golgi organization]
GO:0007165 [signal transduction]
GO:0030054 [cell junction]
GO:0030100 [regulation of endocytosis]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0043547 [positive regulation of GTPase activity]
GO:0051683 [establishment of Golgi localization]
GO:0051684 [maintenance of Golgi location]
GO:0072384 [organelle transport along microtubule]
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 1958 aa
217.5 kDa 		No 0
ARHGAP21-003
ENSP00000405018
ENST00000446003
E7ESW5 [Direct mapping]
Rho GTPase-activating protein 21
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0043547 [positive regulation of GTPase activity]
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 1131 aa
125.6 kDa 		No 0
ARHGAP21-005
ENSP00000402761
ENST00000418325
Q5JSD8 [Direct mapping]
Rho GTPase-activating protein 21
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005096 [GTPase activator activity]
GO:0007165 [signal transduction]
GO:0043547 [positive regulation of GTPase activity]
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 113 aa
13 kDa 		No 0
ARHGAP21-007
ENSP00000400566
ENST00000416305
H0Y5T2 [Direct mapping]
Rho GTPase-activating protein 21
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0043547 [positive regulation of GTPase activity]
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 179 aa
20 kDa 		No 0
ARHGAP21-010
ENSP00000389940
ENST00000418033
H0Y468 [Direct mapping]
Rho GTPase-activating protein 21
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0007165 [signal transduction]
GO:0043547 [positive regulation of GTPase activity]
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 197 aa
22.7 kDa 		No 0
ARHGAP21-012
ENSP00000365592
ENST00000376410
F8W9U9 [Direct mapping]
Rho GTPase-activating protein 21
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0043547 [positive regulation of GTPase activity]
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 1165 aa
129.4 kDa 		No 0
ARHGAP21-201
ENSP00000365604
ENST00000320481
Q5T5U3 [Direct mapping]
Rho GTPase-activating protein 21
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005794 [Golgi apparatus]
GO:0005856 [cytoskeleton]
GO:0007030 [Golgi organization]
GO:0007165 [signal transduction]
GO:0030054 [cell junction]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0043547 [positive regulation of GTPase activity]
GO:0051683 [establishment of Golgi localization]
GO:0051684 [maintenance of Golgi location]
GO:0072384 [organelle transport along microtubule]
Show all
 1407 aa
156.2 kDa 		No 0
ARHGAP21-202
ENSP00000480005
ENST00000612832
A0A087WW76 [Direct mapping]
Rho GTPase-activating protein 21
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0007165 [signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 1406 aa
156 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.