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SUFU

GENERAL INFORMATION

Gene name

 SUFU

Gene description

 Suppressor of fused homolog (Drosophila)

Protein class

 Cancer-related genes
Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA008700
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA008700

GENE INFORMATION

Gene name

 SUFU (HGNC Symbol)

Synonyms

 PRO1280, SUFUH, SUFUXL

Description

 Suppressor of fused homolog (Drosophila) (HGNC Symbol)

Entrez gene summary

 The Hedgehog signaling pathway plays an important role in early human development. The pathway is a signaling cascade that plays a role in pattern formation and cellular proliferation during development. This gene encodes a negative regulator of the hedgehog signaling pathway. Defects in this gene are a cause of medulloblastoma. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

Chromosome

 10

Cytoband

 q24.32

Chromosome location (bp)

 102503987 - 102633535

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000107882 (version 83.38)

Entrez gene

 51684

UniProt

 Q9UMX1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UMX1

Antibodypedia

 SUFU antibodies

PROTEIN BROWSER
SUFU-001
SUFU-004
SUFU-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SUFU-001
ENSP00000358918
ENST00000369902
Q9UMX1 [Direct mapping]
Suppressor of fused homolog
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Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Large Deletions
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001501 [skeletal system development]
GO:0001843 [neural tube closure]
GO:0001947 [heart looping]
GO:0003281 [ventricular septum development]
GO:0003714 [transcription corepressor activity]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005929 [cilium]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006508 [proteolysis]
GO:0007165 [signal transduction]
GO:0007275 [multicellular organismal development]
GO:0007368 [determination of left/right symmetry]
GO:0008013 [beta-catenin binding]
GO:0008134 [transcription factor binding]
GO:0019901 [protein kinase binding]
GO:0021513 [spinal cord dorsal/ventral patterning]
GO:0021775 [smoothened signaling pathway involved in ventral spinal cord interneuron specification]
GO:0021776 [smoothened signaling pathway involved in spinal cord motor neuron cell fate specification]
GO:0035904 [aorta development]
GO:0042992 [negative regulation of transcription factor import into nucleus]
GO:0042994 [cytoplasmic sequestering of transcription factor]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0043588 [skin development]
GO:0045668 [negative regulation of osteoblast differentiation]
GO:0045879 [negative regulation of smoothened signaling pathway]
GO:0060976 [coronary vasculature development]
GO:0072372 [primary cilium]
GO:0097542 [ciliary tip]
GO:0097546 [ciliary base]
GO:1901621 [negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning]
GO:2000059 [negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
Show all
 484 aa
53.9 kDa 		No 0
SUFU-004
ENSP00000358915
ENST00000369899
Q9UMX1 [Direct mapping]
Suppressor of fused homolog
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Large Deletions
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001501 [skeletal system development]
GO:0003714 [transcription corepressor activity]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006508 [proteolysis]
GO:0007165 [signal transduction]
GO:0007275 [multicellular organismal development]
GO:0008134 [transcription factor binding]
GO:0019901 [protein kinase binding]
GO:0042992 [negative regulation of transcription factor import into nucleus]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0045668 [negative regulation of osteoblast differentiation]
GO:0045879 [negative regulation of smoothened signaling pathway]
GO:0097542 [ciliary tip]
GO:0097546 [ciliary base]
Show all
 433 aa
47.9 kDa 		No 0
SUFU-006
ENSP00000411597
ENST00000423559
Q9UMX1 [Direct mapping]
Suppressor of fused homolog
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Large Deletions
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001501 [skeletal system development]
GO:0003714 [transcription corepressor activity]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006508 [proteolysis]
GO:0007165 [signal transduction]
GO:0007275 [multicellular organismal development]
GO:0008134 [transcription factor binding]
GO:0019901 [protein kinase binding]
GO:0042992 [negative regulation of transcription factor import into nucleus]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0045668 [negative regulation of osteoblast differentiation]
GO:0045879 [negative regulation of smoothened signaling pathway]
GO:0097542 [ciliary tip]
GO:0097546 [ciliary base]
Show all
 481 aa
53 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.