Expression of ANKRD26 in cancer - Summary - The Human Protein Atlas

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ANKRD26

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ANKRD26
Gene description	Ankyrin repeat domain 26
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression, which often had a granular pattern.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA040654 , HPA041460
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA040654	HPA041460

GENE INFORMATION
Gene name	ANKRD26 (HGNC Symbol)
Synonyms	KIAA1074, THC2
Description	Ankyrin repeat domain 26 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein containing N-terminal ankyrin repeats which function in protein-protein interactions. Mutations in this gene are associated with autosomal dominant thrombocytopenia-2. Pseudogenes of this gene are found on chromosome 7, 10, 13 and 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Chromosome	10
Cytoband	p12.1
Chromosome location (bp)	26991914 - 27100498
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000107890 (version 83.38)
Entrez gene	22852
UniProt	Q9UPS8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UPS8
Antibodypedia	ANKRD26 antibodies

PROTEIN BROWSER

ANKRD26-001	ANKRD26-003	ANKRD26-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ANKRD26-001 ENSP00000365255 ENST00000376087	Q9UPS8 [Direct mapping] Ankyrin repeat domain-containing protein 26 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005813 [centrosome] Show all	1710 aa 196.4 kDa	No	0
ANKRD26-003 ENSP00000394152 ENST00000445828	H0Y4T9 [Direct mapping] Ankyrin repeat domain-containing protein 26 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		213 aa 24.3 kDa	No	0
ANKRD26-201 ENSP00000405112 ENST00000436985	E7ESJ3 [Direct mapping] Ankyrin repeat domain-containing protein 26 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	1726 aa 198.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.