Fields »
ABOUT
HELP
BLOG
LHPP

GENERAL INFORMATION

Gene name

 LHPP

Gene description

 Phospholysine phosphohistidine inorganic pyrophosphate phosphatase

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA009163 , HPA009269
SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA009163
HPA009269

GENE INFORMATION

Gene name

 LHPP (HGNC Symbol)

Synonyms

 HDHD2B

Description

 Phospholysine phosphohistidine inorganic pyrophosphate phosphatase (HGNC Symbol)

Entrez gene summary

Chromosome

 10

Cytoband

 q26.13

Chromosome location (bp)

 124461834 - 124617888

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000107902 (version 83.38)

Entrez gene

 64077

UniProt

 Q9H008 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H008

Antibodypedia

 LHPP antibodies

PROTEIN BROWSER
LHPP-001
LHPP-003
LHPP-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LHPP-001
ENSP00000357835
ENST00000368842
Q9H008 [Direct mapping]
Phospholysine phosphohistidine inorganic pyrophosphate phosphatase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0004427 [inorganic diphosphatase activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006470 [protein dephosphorylation]
GO:0006796 [phosphate-containing compound metabolic process]
GO:0008969 [phosphohistidine phosphatase activity]
GO:0042803 [protein homodimerization activity]
Show all
 270 aa
29.2 kDa 		No 0
LHPP-003
ENSP00000376512
ENST00000392757
Q5T1Z0 [Direct mapping]
Phospholysine phosphohistidine inorganic pyrophosphate phosphatase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
Show all
 212 aa
22.9 kDa 		No 0
LHPP-007
ENSP00000357832
ENST00000368839
Q9H008 [Direct mapping]
Phospholysine phosphohistidine inorganic pyrophosphate phosphatase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0004427 [inorganic diphosphatase activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006470 [protein dephosphorylation]
GO:0006796 [phosphate-containing compound metabolic process]
GO:0008969 [phosphohistidine phosphatase activity]
GO:0042803 [protein homodimerization activity]
Show all
 210 aa
22.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.