Cell atlas - BCCIP - The Human Protein Atlas

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BCCIP

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	BCCIP
Gene description	BRCA2 and CDKN1A interacting protein
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported)
Additional location	In addition localized to the Cytosol (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA038011
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the cytosol.

Main location

Nucleoplasm (supported)

Additional location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA038011	HEK 293	Nucleoplasm	Intensity
	HPA038011	HEK 293	Cytosol
	HPA038011	PC-3	Nucleoplasm
	HPA038011	PC-3	Cytosol

GENE INFORMATION
Gene name	BCCIP (HGNC Symbol)
Synonyms	BCCIPalpha, TOK-1
Description	BRCA2 and CDKN1A interacting protein (HGNC Symbol)
Entrez gene summary	This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Chromosome	10
Cytoband	q26.2
Chromosome location (bp)	125823546 - 125853695
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000107949 (version 83.38)
Entrez gene	56647
UniProt	Q9P287 (UniProt - Evidence at protein level)
neXtProt	NX_Q9P287
Antibodypedia	BCCIP antibodies

PROTEIN BROWSER

BCCIP-001	BCCIP-002	BCCIP-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BCCIP-001 ENSP00000357748 ENST00000368759	Q9P287 [Direct mapping] BRCA2 and CDKN1A-interacting protein Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006281 [DNA repair] GO:0006974 [cellular response to DNA damage stimulus] GO:0007049 [cell cycle] GO:0019207 [kinase regulator activity] GO:0019908 [nuclear cyclin-dependent protein kinase holoenzyme complex] GO:0044822 [poly(A) RNA binding] GO:0061101 [neuroendocrine cell differentiation] Show all	322 aa 36.2 kDa	No	0
BCCIP-002 ENSP00000278100 ENST00000278100	Q9P287 [Direct mapping] BRCA2 and CDKN1A-interacting protein Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006281 [DNA repair] GO:0007049 [cell cycle] GO:0019207 [kinase regulator activity] GO:0019908 [nuclear cyclin-dependent protein kinase holoenzyme complex] GO:0044822 [poly(A) RNA binding] GO:0061101 [neuroendocrine cell differentiation] Show all	314 aa 36 kDa	No	0
BCCIP-003 ENSP00000299130 ENST00000299130	Q9P287 [Direct mapping] BRCA2 and CDKN1A-interacting protein Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006281 [DNA repair] GO:0007049 [cell cycle] GO:0019207 [kinase regulator activity] GO:0019908 [nuclear cyclin-dependent protein kinase holoenzyme complex] GO:0044822 [poly(A) RNA binding] GO:0061101 [neuroendocrine cell differentiation] Show all	292 aa 33.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.