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EBF3

GENERAL INFORMATION

Gene name

 EBF3

Gene description

 Early B-cell factor 3

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (LHCN-M2, NB-4, RH-30, SCLC-21H)
HPA (normal tissue):Tissue enhanced (adipose tissue)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 EBF3 (HGNC Symbol)

Synonyms

 COE3, DKFZp667B0210

Description

 Early B-cell factor 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the early B-cell factor (EBF) family of DNA binding transcription factors. EBF proteins are involved in B-cell differentiation, bone development and neurogenesis, and may also function as tumor suppressors. The encoded protein inhibits cell survival through the regulation of genes involved in cell cycle arrest and apoptosis, and aberrant methylation or deletion of this gene may play a role in multiple malignancies including glioblastoma multiforme and gastric carcinoma. [provided by RefSeq, Sep 2011]

Chromosome

 10

Cytoband

 q26.3

Chromosome location (bp)

 129835283 - 129963841

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000108001 (version 83.38)

Entrez gene

 253738

UniProt

 Q9H4W6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H4W6

Antibodypedia

 EBF3 antibodies

PROTEIN BROWSER
EBF3-001
EBF3-002
EBF3-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EBF3-001
ENSP00000347463
ENST00000355311
Q9H4W6 [Direct mapping]
Transcription factor COE3
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Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
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GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0007275 [multicellular organismal development]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0046983 [protein dimerization activity]
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 596 aa
64.9 kDa 		No 0
EBF3-002
ENSP00000357637
ENST00000368648
Q9H4W6 [Direct mapping]
Transcription factor COE3
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Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007275 [multicellular organismal development]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0046983 [protein dimerization activity]
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 551 aa
60.4 kDa 		No 0
EBF3-004
ENSP00000387543
ENST00000440978
H0Y3W9 [Direct mapping]
Transcription factor COE3
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Predicted intracellular proteins
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GO:0003677 [DNA binding]
GO:0006355 [regulation of transcription, DNA-templated]
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 191 aa
19.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.