Expression of XPNPEP1 in cancer - Summary

GENERAL INFORMATION
Gene name	XPNPEP1
Gene description	X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression at variable levels in most tissues, most abundant in exocrine pancreas and the intestine.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 4 antibodies. HPA030419 , HPA030420 , HPA030422 , CAB025196
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA030419	HPA030420	HPA030422	CAB025196

GENE INFORMATION
Gene name	XPNPEP1 (HGNC Symbol)
Synonyms	XPNPEP, XPNPEPL, XPNPEPL1
Description	X-prolyl aminopeptidase (aminopeptidase P) 1, soluble (HGNC Symbol)
Entrez gene summary	This gene encodes the cytosolic form of a metalloaminopeptidase that catalyzes the cleavage of the N-terminal amino acid adjacent to a proline residue. The gene product may play a role in degradation and maturation of tachykinins, neuropeptides, and peptide hormones. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Nov 2009]
Chromosome	10
Cytoband	q25.1
Chromosome location (bp)	109864766 - 109923553
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000108039 (version 83.38)
Entrez gene	7511
UniProt	Q9NQW7 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NQW7
Antibodypedia	XPNPEP1 antibodies

PROTEIN BROWSER

XPNPEP1-002	XPNPEP1-004	XPNPEP1-015	XPNPEP1-016	XPNPEP1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
XPNPEP1-002 ENSP00000385388 ENST00000403138	Q5T6H2 [Direct mapping] Xaa-Pro aminopeptidase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0008152 [metabolic process] GO:0016787 [hydrolase activity] Show all	303 aa 34.4 kDa	No	0
XPNPEP1-004 ENSP00000410318 ENST00000423625	Q5T6H3 [Direct mapping] Xaa-Pro aminopeptidase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016787 [hydrolase activity] Show all	233 aa 26.3 kDa	No	0
XPNPEP1-015 ENSP00000421566 ENST00000502935	Q9NQW7 [Direct mapping] Xaa-Pro aminopeptidase 1 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004177 [aminopeptidase activity] GO:0005737 [cytoplasm] GO:0006508 [proteolysis] GO:0010815 [bradykinin catabolic process] GO:0016787 [hydrolase activity] GO:0030145 [manganese ion binding] GO:0042803 [protein homodimerization activity] GO:0070006 [metalloaminopeptidase activity] GO:0070062 [extracellular exosome] Show all	666 aa 74.8 kDa	No	0
XPNPEP1-016 ENSP00000358697 ENST00000369683	Q5T6H7 [Direct mapping] Xaa-Pro aminopeptidase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0008152 [metabolic process] GO:0016787 [hydrolase activity] GO:0046872 [metal ion binding] Show all	552 aa 62.1 kDa	No	0
XPNPEP1-201 ENSP00000324011 ENST00000322238	Q9NQW7 [Direct mapping] Xaa-Pro aminopeptidase 1 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004177 [aminopeptidase activity] GO:0005737 [cytoplasm] GO:0006508 [proteolysis] GO:0010815 [bradykinin catabolic process] GO:0016787 [hydrolase activity] GO:0030145 [manganese ion binding] GO:0042803 [protein homodimerization activity] GO:0070006 [metalloaminopeptidase activity] GO:0070062 [extracellular exosome] Show all	642 aa 72.1 kDa	No	0