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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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SMC3
  • TISSUE

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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

SMC3

Gene description

Structural maintenance of chromosomes 3

Protein class

Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic and nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Uncertain based on 1 antibody.
HPA037411
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PROGNOSTIC SUMMARY

Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA037411

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Weak to moderate nuclear and cytoplasmic staining was displayed by malignant cells.

GENE INFORMATION

Gene name

SMC3 (HGNC Symbol)

Synonyms

BAM, bamacan, CSPG6, HCAP, SMC3L1

Description

Structural maintenance of chromosomes 3 (HGNC Symbol)

Entrez gene summary

This gene belongs to the SMC3 subfamily of SMC proteins. The encoded protein occurs in certain cell types as either an intracellular, nuclear protein or a secreted protein. The nuclear form, known as structural maintenance of chromosomes 3, is a component of the multimeric cohesin complex that holds together sister chromatids during mitosis, enabling proper chromosome segregation. Post-translational modification of the encoded protein by the addition of chondroitin sulfate chains gives rise to the secreted proteoglycan bamacan, an abundant basement membrane protein. [provided by RefSeq, Jul 2008]

Chromosome

10

Cytoband

q25.2

Chromosome location (bp)

110567691 - 110604636

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000108055 (version 83.38)

Entrez gene

9126

UniProt

Q9UQE7 (UniProt - Evidence at protein level)

neXtProt

NX_Q9UQE7

Antibodypedia

SMC3 antibodies

PROTEIN BROWSER

SMC3-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SMC3-001
ENSP00000354720
ENST00000361804
Q9UQE7 [Direct mapping]
Structural maintenance of chromosomes protein 3
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000775 [chromosome, centromeric region]
GO:0000785 [chromatin]
GO:0000800 [lateral element]
GO:0000922 [spindle pole]
GO:0003682 [chromatin binding]
GO:0003777 [microtubule motor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005604 [basement membrane]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006275 [regulation of DNA replication]
GO:0006281 [DNA repair]
GO:0007052 [mitotic spindle organization]
GO:0007062 [sister chromatid cohesion]
GO:0007064 [mitotic sister chromatid cohesion]
GO:0007067 [mitotic nuclear division]
GO:0007126 [meiotic nuclear division]
GO:0007165 [signal transduction]
GO:0008278 [cohesin complex]
GO:0008280 [cohesin core heterodimer]
GO:0016363 [nuclear matrix]
GO:0016925 [protein sumoylation]
GO:0019827 [stem cell population maintenance]
GO:0030893 [meiotic cohesin complex]
GO:0032876 [negative regulation of DNA endoreduplication]
GO:0034991 [nuclear meiotic cohesin complex]
GO:0036033 [mediator complex binding]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0045502 [dynein binding]
GO:0046982 [protein heterodimerization activity]
GO:0051276 [chromosome organization]
GO:0051301 [cell division]
Show all
1217 aa
141.5 kDa
No 0

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