Fields »
ABOUT
HELP
BLOG
CCNY

GENERAL INFORMATION

Gene name

 CCNY

Gene description

 Cyclin Y

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General membranous and cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA036290
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA036290

GENE INFORMATION

Gene name

 CCNY (HGNC Symbol)

Synonyms

 C10orf9, CBCP1, CFP1

Description

 Cyclin Y (HGNC Symbol)

Entrez gene summary

 Cyclins, such as CCNY, control cell division cycles and regulate cyclin-dependent kinases (e.g., CDC2; MIM 116940) (Li et al., 2009 [PubMed 18060517]).[supplied by OMIM, May 2009]

Chromosome

 10

Cytoband

 p11.21

Chromosome location (bp)

 35247025 - 35572669

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000108100 (version 83.38)

Entrez gene

 219771

UniProt

 Q8ND76 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8ND76

Antibodypedia

 CCNY antibodies

PROTEIN BROWSER
CCNY-001
CCNY-002
CCNY-004
CCNY-007
CCNY-201
CCNY-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CCNY-001
ENSP00000363838
ENST00000374706
Q8ND76 [Direct mapping]
Cyclin-Y
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000308 [cytoplasmic cyclin-dependent protein kinase holoenzyme complex]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005886 [plasma membrane]
GO:0016055 [Wnt signaling pathway]
GO:0016538 [cyclin-dependent protein serine/threonine kinase regulator activity]
GO:0019901 [protein kinase binding]
GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0051301 [cell division]
GO:0060828 [regulation of canonical Wnt signaling pathway]
GO:0070062 [extracellular exosome]
Show all
 287 aa
33.2 kDa 		No 0
CCNY-002
ENSP00000363836
ENST00000374704
Q8ND76 [Direct mapping]
Cyclin-Y
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000308 [cytoplasmic cyclin-dependent protein kinase holoenzyme complex]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005886 [plasma membrane]
GO:0016055 [Wnt signaling pathway]
GO:0016538 [cyclin-dependent protein serine/threonine kinase regulator activity]
GO:0019901 [protein kinase binding]
GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0051301 [cell division]
GO:0060828 [regulation of canonical Wnt signaling pathway]
GO:0070062 [extracellular exosome]
Show all
 341 aa
39.3 kDa 		No 0
CCNY-004
ENSP00000473487
ENST00000490012
R4GN48 [Direct mapping]
Cyclin-Y
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 52 aa
6 kDa 		No 0
CCNY-007
ENSP00000473625
ENST00000493157
R4GNF3 [Direct mapping]
Cyclin-Y
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 101 aa
11.6 kDa 		No 0
CCNY-201
ENSP00000265375
ENST00000265375
Q8ND76 [Direct mapping]
Cyclin-Y
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000308 [cytoplasmic cyclin-dependent protein kinase holoenzyme complex]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005886 [plasma membrane]
GO:0016055 [Wnt signaling pathway]
GO:0016538 [cyclin-dependent protein serine/threonine kinase regulator activity]
GO:0019901 [protein kinase binding]
GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0051301 [cell division]
GO:0060828 [regulation of canonical Wnt signaling pathway]
GO:0070062 [extracellular exosome]
Show all
 287 aa
33.2 kDa 		No 0
CCNY-202
ENSP00000344275
ENST00000339497
Q8ND76 [Direct mapping]
Cyclin-Y
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000308 [cytoplasmic cyclin-dependent protein kinase holoenzyme complex]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005886 [plasma membrane]
GO:0016055 [Wnt signaling pathway]
GO:0016538 [cyclin-dependent protein serine/threonine kinase regulator activity]
GO:0019901 [protein kinase binding]
GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0051301 [cell division]
GO:0060828 [regulation of canonical Wnt signaling pathway]
GO:0070062 [extracellular exosome]
Show all
 316 aa
36.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.