Expression of UBE2S in cancer - Summary

GENERAL INFORMATION
Gene name	UBE2S
Gene description	Ubiquitin-conjugating enzyme E2S
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in seminiferous ducts and a subset of cells in squamous epithelia, urinary bladder and lymphoid tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA057150 , CAB015228
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), liver cancer (unfavourable) and endometrial cancer (unfavourable).
Renal cancer p<0.001 Liver cancer p<0.001 Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA057150	CAB015228

GENE INFORMATION
Gene name	UBE2S (HGNC Symbol)
Synonyms	E2-EPF
Description	Ubiquitin-conjugating enzyme E2S (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the ubiquitin-conjugating enzyme family. The encoded protein is able to form a thiol ester linkage with ubiquitin in a ubiquitin activating enzyme-dependent manner, a characteristic property of ubiquitin carrier proteins. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	q13.42
Chromosome location (bp)	55399745 - 55407777
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000108106 (version 83.38)
Entrez gene	27338
UniProt	Q16763 (UniProt - Evidence at protein level)
neXtProt	NX_Q16763
Antibodypedia	UBE2S antibodies

PROTEIN BROWSER

UBE2S-001	UBE2S-002	UBE2S-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
UBE2S-001 ENSP00000264552 ENST00000264552	Q16763 [Direct mapping] Ubiquitin-conjugating enzyme E2 S Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005524 [ATP binding] GO:0005680 [anaphase-promoting complex] GO:0005737 [cytoplasm] GO:0006464 [cellular protein modification process] GO:0010458 [exit from mitosis] GO:0010994 [free ubiquitin chain polymerization] GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0031625 [ubiquitin protein ligase binding] GO:0035519 [protein K29-linked ubiquitination] GO:0044314 [protein K27-linked ubiquitination] GO:0051301 [cell division] GO:0051488 [activation of anaphase-promoting complex activity] GO:0061630 [ubiquitin protein ligase activity] GO:0061631 [ubiquitin conjugating enzyme activity] GO:0070534 [protein K63-linked ubiquitination] GO:0070979 [protein K11-linked ubiquitination] GO:0085020 [protein K6-linked ubiquitination] Show all	222 aa 23.8 kDa	No	0
UBE2S-002 ENSP00000467409 ENST00000587845	K7EPJ1 [Direct mapping] Ubiquitin-conjugating enzyme E2 S Show all	MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0031625 [ubiquitin protein ligase binding] GO:0061630 [ubiquitin protein ligase activity] Show all	204 aa 22.4 kDa	No	0
UBE2S-003 ENSP00000466388 ENST00000589978	K7EM75 [Direct mapping] Ubiquitin-conjugating enzyme E2 S Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0016567 [protein ubiquitination] GO:0031625 [ubiquitin protein ligase binding] GO:0061630 [ubiquitin protein ligase activity] Show all	79 aa 8.9 kDa	No	0