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RPL28

GENERAL INFORMATION

Gene name

 RPL28

Gene description

 Ribosomal protein L28

Protein class

 Predicted intracellular proteins
Ribosomal proteins

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA050459
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA050459

GENE INFORMATION

Gene name

 RPL28 (HGNC Symbol)

Synonyms

 FLJ43307, L28

Description

 Ribosomal protein L28 (HGNC Symbol)

Entrez gene summary

 Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L28E family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]

Chromosome

 19

Cytoband

 q13.42

Chromosome location (bp)

 55385345 - 55403250

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000108107 (version 83.38)

Entrez gene

 6158

UniProt

 P46779 (UniProt - Evidence at protein level)

neXtProt

 NX_P46779

Antibodypedia

 RPL28 antibodies

PROTEIN BROWSER
RPL28-001
RPL28-002
RPL28-003
RPL28-004
RPL28-005
RPL28-006
RPL28-007
RPL28-008
RPL28-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RPL28-001
ENSP00000342787
ENST00000344063
P46779 [Direct mapping]
60S ribosomal protein L28
Show all
Ribosomal proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0003723 [RNA binding]
GO:0003735 [structural constituent of ribosome]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006414 [translational elongation]
GO:0006415 [translational termination]
GO:0006614 [SRP-dependent cotranslational protein targeting to membrane]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019058 [viral life cycle]
GO:0019083 [viral transcription]
GO:0022625 [cytosolic large ribosomal subunit]
GO:0030425 [dendrite]
GO:0036464 [cytoplasmic ribonucleoprotein granule]
GO:0044267 [cellular protein metabolic process]
GO:0044297 [cell body]
GO:0044822 [poly(A) RNA binding]
GO:0070062 [extracellular exosome]
GO:1903146 [regulation of mitophagy]
GO:1903955 [positive regulation of protein targeting to mitochondrion]
Show all
 137 aa
15.7 kDa 		No 0
RPL28-002
ENSP00000453029
ENST00000560583
P46779 [Direct mapping]
60S ribosomal protein L28
Show all
Ribosomal proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0003723 [RNA binding]
GO:0003735 [structural constituent of ribosome]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006414 [translational elongation]
GO:0006415 [translational termination]
GO:0006614 [SRP-dependent cotranslational protein targeting to membrane]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019058 [viral life cycle]
GO:0019083 [viral transcription]
GO:0022625 [cytosolic large ribosomal subunit]
GO:0030425 [dendrite]
GO:0036464 [cytoplasmic ribonucleoprotein granule]
GO:0044267 [cellular protein metabolic process]
GO:0044297 [cell body]
GO:0044822 [poly(A) RNA binding]
GO:0070062 [extracellular exosome]
GO:1903146 [regulation of mitophagy]
GO:1903955 [positive regulation of protein targeting to mitochondrion]
Show all
 163 aa
18.4 kDa 		No 0
RPL28-003
ENSP00000391665
ENST00000428193
P46779 [Direct mapping]
60S ribosomal protein L28
Show all
Ribosomal proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0003723 [RNA binding]
GO:0003735 [structural constituent of ribosome]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006414 [translational elongation]
GO:0006415 [translational termination]
GO:0006614 [SRP-dependent cotranslational protein targeting to membrane]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019058 [viral life cycle]
GO:0019083 [viral transcription]
GO:0022625 [cytosolic large ribosomal subunit]
GO:0030425 [dendrite]
GO:0036464 [cytoplasmic ribonucleoprotein granule]
GO:0044267 [cellular protein metabolic process]
GO:0044297 [cell body]
GO:0044822 [poly(A) RNA binding]
GO:0070062 [extracellular exosome]
GO:1903146 [regulation of mitophagy]
GO:1903955 [positive regulation of protein targeting to mitochondrion]
Show all
 69 aa
7.9 kDa 		No 0
RPL28-004
ENSP00000400596
ENST00000431533
P46779 [Direct mapping]
60S ribosomal protein L28
Show all
Ribosomal proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0003723 [RNA binding]
GO:0003735 [structural constituent of ribosome]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006414 [translational elongation]
GO:0006415 [translational termination]
GO:0006614 [SRP-dependent cotranslational protein targeting to membrane]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019058 [viral life cycle]
GO:0019083 [viral transcription]
GO:0022625 [cytosolic large ribosomal subunit]
GO:0030425 [dendrite]
GO:0036464 [cytoplasmic ribonucleoprotein granule]
GO:0044267 [cellular protein metabolic process]
GO:0044297 [cell body]
GO:0044822 [poly(A) RNA binding]
GO:0070062 [extracellular exosome]
GO:1903146 [regulation of mitophagy]
GO:1903955 [positive regulation of protein targeting to mitochondrion]
Show all
 87 aa
10.1 kDa 		No 0
RPL28-005
ENSP00000452909
ENST00000558815
P46779 [Direct mapping]
60S ribosomal protein L28
Show all
Ribosomal proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0003723 [RNA binding]
GO:0003735 [structural constituent of ribosome]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006414 [translational elongation]
GO:0006415 [translational termination]
GO:0006614 [SRP-dependent cotranslational protein targeting to membrane]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019058 [viral life cycle]
GO:0019083 [viral transcription]
GO:0022625 [cytosolic large ribosomal subunit]
GO:0030425 [dendrite]
GO:0036464 [cytoplasmic ribonucleoprotein granule]
GO:0044267 [cellular protein metabolic process]
GO:0044297 [cell body]
GO:0044822 [poly(A) RNA binding]
GO:0070062 [extracellular exosome]
GO:1903146 [regulation of mitophagy]
GO:1903955 [positive regulation of protein targeting to mitochondrion]
Show all
 169 aa
19.1 kDa 		No 0
RPL28-006
ENSP00000453319
ENST00000559463
P46779 [Direct mapping]
60S ribosomal protein L28
Show all
Ribosomal proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0003723 [RNA binding]
GO:0003735 [structural constituent of ribosome]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006414 [translational elongation]
GO:0006415 [translational termination]
GO:0006614 [SRP-dependent cotranslational protein targeting to membrane]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019058 [viral life cycle]
GO:0019083 [viral transcription]
GO:0022625 [cytosolic large ribosomal subunit]
GO:0030425 [dendrite]
GO:0036464 [cytoplasmic ribonucleoprotein granule]
GO:0044267 [cellular protein metabolic process]
GO:0044297 [cell body]
GO:0044822 [poly(A) RNA binding]
GO:0070062 [extracellular exosome]
GO:1903146 [regulation of mitophagy]
GO:1903955 [positive regulation of protein targeting to mitochondrion]
Show all
 137 aa
15.7 kDa 		No 0
RPL28-007
ENSP00000452763
ENST00000560055
H0YKD8 [Direct mapping]
60S ribosomal protein L28
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003735 [structural constituent of ribosome]
GO:0005840 [ribosome]
GO:0006412 [translation]
Show all
 170 aa
19.1 kDa 		No 0
RPL28-008
ENSP00000453584
ENST00000558752
H0YMF4 [Direct mapping]
60S ribosomal protein L28
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003735 [structural constituent of ribosome]
GO:0005840 [ribosome]
GO:0006412 [translation]
Show all
 112 aa
12.4 kDa 		No 0
RPL28-011
ENSP00000453285
ENST00000558131
H0YLP6 [Direct mapping]
60S ribosomal protein L28
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003735 [structural constituent of ribosome]
GO:0005840 [ribosome]
GO:0006412 [translation]
Show all
 89 aa
9.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.