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CDK5RAP3

GENERAL INFORMATION

Gene name

 CDK5RAP3

Gene description

 CDK5 regulatory subunit associated protein 3

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA022141 , HPA022882 , HPA027883
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and urothelial cancer (favourable).
Renal cancer p<0.001
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA022141
HPA022882
HPA027883

GENE INFORMATION

Gene name

 CDK5RAP3 (HGNC Symbol)

Synonyms

 C53, FLJ13660, HSF-27, IC53, LZAP, MST016, OK/SW-cl.114

Description

 CDK5 regulatory subunit associated protein 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that has been reported to function in signaling pathways governing transcriptional regulation and cell cycle progression. It may play a role in tumorigenesis and metastasis. A pseudogene of this gene is located on the long arm of chromosome 20. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, May 2013]

Chromosome

 17

Cytoband

 q21.32

Chromosome location (bp)

 47967810 - 47981774

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000108465 (version 83.38)

Entrez gene

 80279

UniProt

 Q96JB5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96JB5

Antibodypedia

 CDK5RAP3 antibodies

PROTEIN BROWSER
CDK5RAP3-001
CDK5RAP3-010
CDK5RAP3-011
CDK5RAP3-012
CDK5RAP3-017
CDK5RAP3-033
CDK5RAP3-037

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CDK5RAP3-001
ENSP00000344683
ENST00000338399
Q96JB5 [Direct mapping]
CDK5 regulatory subunit-associated protein 3
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005874 [microtubule]
GO:0007095 [mitotic G2 DNA damage checkpoint]
GO:0007420 [brain development]
GO:0008283 [cell proliferation]
GO:0010921 [regulation of phosphatase activity]
GO:0012505 [endomembrane system]
GO:0016020 [membrane]
GO:0019901 [protein kinase binding]
GO:0030262 [apoptotic nuclear changes]
GO:0030332 [cyclin binding]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0043234 [protein complex]
GO:0043407 [negative regulation of MAP kinase activity]
GO:0044387 [negative regulation of protein kinase activity by regulation of protein phosphorylation]
GO:0044389 [ubiquitin-like protein ligase binding]
GO:0044818 [mitotic G2/M transition checkpoint]
GO:0045664 [regulation of neuron differentiation]
GO:0051019 [mitogen-activated protein kinase binding]
GO:0051059 [NF-kappaB binding]
GO:0071569 [protein ufmylation]
GO:0071901 [negative regulation of protein serine/threonine kinase activity]
GO:0097371 [MDM2/MDM4 family protein binding]
GO:1900182 [positive regulation of protein localization to nucleus]
GO:1901798 [positive regulation of signal transduction by p53 class mediator]
GO:1903363 [negative regulation of cellular protein catabolic process]
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 506 aa
56.9 kDa 		No 0
CDK5RAP3-010
ENSP00000438886
ENST00000536708
Q96JB5 [Direct mapping]
CDK5 regulatory subunit-associated protein 3
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005874 [microtubule]
GO:0007095 [mitotic G2 DNA damage checkpoint]
GO:0007420 [brain development]
GO:0008283 [cell proliferation]
GO:0010921 [regulation of phosphatase activity]
GO:0012505 [endomembrane system]
GO:0016020 [membrane]
GO:0019901 [protein kinase binding]
GO:0030262 [apoptotic nuclear changes]
GO:0030332 [cyclin binding]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0032403 [protein complex binding]
GO:0043234 [protein complex]
GO:0043407 [negative regulation of MAP kinase activity]
GO:0044387 [negative regulation of protein kinase activity by regulation of protein phosphorylation]
GO:0044389 [ubiquitin-like protein ligase binding]
GO:0044818 [mitotic G2/M transition checkpoint]
GO:0045664 [regulation of neuron differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0051019 [mitogen-activated protein kinase binding]
GO:0051059 [NF-kappaB binding]
GO:0071569 [protein ufmylation]
GO:0071901 [negative regulation of protein serine/threonine kinase activity]
GO:0097371 [MDM2/MDM4 family protein binding]
GO:1900182 [positive regulation of protein localization to nucleus]
GO:1901798 [positive regulation of signal transduction by p53 class mediator]
GO:1903363 [negative regulation of cellular protein catabolic process]
Show all
 531 aa
59.6 kDa 		No 0
CDK5RAP3-011
ENSP00000464542
ENST00000579632
J3QS62 [Direct mapping]
CDK5 regulatory subunit-associated protein 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0012505 [endomembrane system]
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 196 aa
22.8 kDa 		No 0
CDK5RAP3-012
ENSP00000462886
ENST00000578018
J3KTA5 [Direct mapping]
CDK5 regulatory subunit-associated protein 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0012505 [endomembrane system]
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 64 aa
7.6 kDa 		No 0
CDK5RAP3-017
ENSP00000463431
ENST00000583352
J3QL86 [Direct mapping]
CDK5 regulatory subunit-associated protein 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0012505 [endomembrane system]
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 123 aa
13.9 kDa 		No 0
CDK5RAP3-033
ENSP00000464286
ENST00000583697
J3QRM1 [Direct mapping]
CDK5 regulatory subunit-associated protein 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0012505 [endomembrane system]
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 272 aa
30.1 kDa 		No 0
CDK5RAP3-037
ENSP00000463950
ENST00000579175
J3QQY1 [Direct mapping]
CDK5 regulatory subunit-associated protein 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0012505 [endomembrane system]
Show all
 281 aa
32 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.