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CBX1

GENERAL INFORMATION

Gene name

 CBX1

Gene description

 Chromobox homolog 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
CAB012265
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB012265

GENE INFORMATION

Gene name

 CBX1 (HGNC Symbol)

Synonyms

 CBX, HP1-BETA, HP1Hs-beta, M31, MOD1

Description

 Chromobox homolog 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression. Several related pseudogenes are located on chromosomes 1, 3, and X. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 q21.32

Chromosome location (bp)

 48070052 - 48101521

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000108468 (version 83.38)

Entrez gene

 10951

UniProt

 P83916 (UniProt - Evidence at protein level)

neXtProt

 NX_P83916

Antibodypedia

 CBX1 antibodies

PROTEIN BROWSER
CBX1-001
CBX1-002
CBX1-003
CBX1-004
CBX1-005
CBX1-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CBX1-001
ENSP00000225603
ENST00000225603
P83916 [Direct mapping]
Chromobox protein homolog 1
Q6IBN6 [Target identity:100%; Query identity:100%]
CBX1 protein; Chromobox homolog 1 (HP1 beta homolog Drosophila ), isoform CRA_a; cDNA, FLJ92997, Homo sapiens chromobox homolog 1 (HP1 beta homolog Drosophila ) (CBX1), mRNA
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000775 [chromosome, centromeric region]
GO:0000784 [nuclear chromosome, telomeric region]
GO:0000785 [chromatin]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005720 [nuclear heterochromatin]
GO:0005819 [spindle]
GO:0019899 [enzyme binding]
GO:1990226 [histone methyltransferase binding]
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 185 aa
21.4 kDa 		No 0
CBX1-002
ENSP00000377060
ENST00000393408
P83916 [Direct mapping]
Chromobox protein homolog 1
Q6IBN6 [Target identity:100%; Query identity:100%]
CBX1 protein; Chromobox homolog 1 (HP1 beta homolog Drosophila ), isoform CRA_a; cDNA, FLJ92997, Homo sapiens chromobox homolog 1 (HP1 beta homolog Drosophila ) (CBX1), mRNA
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000775 [chromosome, centromeric region]
GO:0000784 [nuclear chromosome, telomeric region]
GO:0000785 [chromatin]
GO:0001939 [female pronucleus]
GO:0001940 [male pronucleus]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005720 [nuclear heterochromatin]
GO:0005721 [pericentric heterochromatin]
GO:0005819 [spindle]
GO:0010369 [chromocenter]
GO:0019899 [enzyme binding]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:1990226 [histone methyltransferase binding]
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 185 aa
21.4 kDa 		No 0
CBX1-003
ENSP00000393179
ENST00000444685
C9JWS9 [Direct mapping]
Chromobox protein homolog 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005634 [nucleus]
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 110 aa
12.8 kDa 		No 0
CBX1-004
ENSP00000385413
ENST00000402583
B5MD17 [Direct mapping]
Chromobox protein homolog 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005634 [nucleus]
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 168 aa
19.3 kDa 		No 0
CBX1-005
ENSP00000465985
ENST00000495350
K7ELA4 [Direct mapping]
Chromobox protein homolog 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005634 [nucleus]
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 138 aa
16 kDa 		No 0
CBX1-006
ENSP00000462242
ENST00000581003
J3KS05 [Direct mapping]
Chromobox protein homolog 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005634 [nucleus]
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 174 aa
20.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.