Tissue expression of MED13 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	MED13
Gene description	Mediator complex subunit 13
Protein class	Cancer-related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Mixed

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Mixed

GENE INFORMATION
Gene name	MED13 (HGNC Symbol)
Synonyms	KIAA0593, THRAP1, TRAP240
Description	Mediator complex subunit 13 (HGNC Symbol)
Entrez gene summary	This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. The product of this gene is proposed to form a sub-complex with MED12, cyclin C, and CDK8 that can negatively regulate transactivation by mediator. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q23.2
Chromosome location (bp)	61942605 - 62065282
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000108510 (version 83.38)
Entrez gene	9969
UniProt	Q9UHV7 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UHV7
Antibodypedia	MED13 antibodies

PROTEIN BROWSER

MED13-001	MED13-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MED13-001 ENSP00000380888 ENST00000397786	Q9UHV7 [Direct mapping] Mediator of RNA polymerase II transcription subunit 13 A0A024QZ75 [Target identity:100%; Query identity:100%] Thyroid hormone receptor associated protein 1, isoform CRA_b Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001104 [RNA polymerase II transcription cofactor activity] GO:0003712 [transcription cofactor activity] GO:0003713 [transcription coactivator activity] GO:0004872 [receptor activity] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0010467 [gene expression] GO:0016020 [membrane] GO:0016592 [mediator complex] GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity] GO:0030518 [intracellular steroid hormone receptor signaling pathway] GO:0030521 [androgen receptor signaling pathway] GO:0042632 [cholesterol homeostasis] GO:0042809 [vitamin D receptor binding] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046966 [thyroid hormone receptor binding] GO:0070328 [triglyceride homeostasis] GO:1904168 [negative regulation of thyroid hormone receptor activity] Show all	2174 aa 239.3 kDa	No	0
MED13-003 ENSP00000464131 ENST00000583958	J3QRB7 [Direct mapping] Mediator of RNA polymerase II transcription subunit 13 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all		327 aa 36.4 kDa	No	0