Expression of RNF167 in cancer - Summary - The Human Protein Atlas

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RNF167

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	RNF167
Gene description	Ring finger protein 167
Protein class	Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA049810
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable) and renal cancer (favourable).
Pancreatic cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA049810

GENE INFORMATION
Gene name	RNF167 (HGNC Symbol)
Synonyms	DKFZP566H073
Description	Ring finger protein 167 (HGNC Symbol)
Entrez gene summary	RNF167 is an E3 ubiquitin ligase that interacts with TSSC5 (SLC22A18; MIM 602631) and, together with UBCH6 (UBE2E1; MIM 602916), facilitates TSSC5 polyubiquitylation (Yamada and Gorbsky, 2006 [PubMed 16314844]).[supplied by OMIM, Mar 2008]
Chromosome	17
Cytoband	p13.2
Chromosome location (bp)	4940008 - 4945222
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000108523 (version 83.38)
Entrez gene	26001
UniProt	Q9H6Y7 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H6Y7
Antibodypedia	RNF167 antibodies

PROTEIN BROWSER

RNF167-001	RNF167-002	RNF167-003	RNF167-004	RNF167-005	RNF167-008	RNF167-009	RNF167-010	RNF167-013	RNF167-016

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RNF167-001 ENSP00000262482 ENST00000262482	Q9H6Y7 [Direct mapping] E3 ubiquitin-protein ligase RNF167 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000209 [protein polyubiquitination] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0008270 [zinc ion binding] GO:0012505 [endomembrane system] GO:0016021 [integral component of membrane] GO:0016874 [ligase activity] GO:0045786 [negative regulation of cell cycle] Show all	350 aa 38.3 kDa	Yes	1
RNF167-002 ENSP00000460190 ENST00000575111	Q9H6Y7 [Direct mapping] E3 ubiquitin-protein ligase RNF167 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000209 [protein polyubiquitination] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0008270 [zinc ion binding] GO:0012505 [endomembrane system] GO:0016021 [integral component of membrane] GO:0016874 [ligase activity] GO:0045786 [negative regulation of cell cycle] Show all	350 aa 38.3 kDa	Yes	1
RNF167-003 ENSP00000459324 ENST00000571816	Q9H6Y7 [Direct mapping] E3 ubiquitin-protein ligase RNF167 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000209 [protein polyubiquitination] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0008270 [zinc ion binding] GO:0012505 [endomembrane system] GO:0016021 [integral component of membrane] GO:0016874 [ligase activity] GO:0045786 [negative regulation of cell cycle] Show all	350 aa 38.3 kDa	Yes	1
RNF167-004 ENSP00000458794 ENST00000572430	Q9H6Y7 [Direct mapping] E3 ubiquitin-protein ligase RNF167 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000209 [protein polyubiquitination] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0008270 [zinc ion binding] GO:0012505 [endomembrane system] GO:0016021 [integral component of membrane] GO:0016874 [ligase activity] GO:0045786 [negative regulation of cell cycle] Show all	350 aa 38.3 kDa	Yes	1
RNF167-005 ENSP00000458189 ENST00000576229	I3L0L6 [Direct mapping] E3 ubiquitin-protein ligase RNF167 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] Show all	315 aa 34.7 kDa	No	1
RNF167-008 ENSP00000459581 ENST00000573404	I3L2D4 [Direct mapping] E3 ubiquitin-protein ligase RNF167 Show all	TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		122 aa 12.8 kDa	Yes	0
RNF167-009 ENSP00000458375 ENST00000576452	I3L0V7 [Direct mapping] E3 ubiquitin-protein ligase RNF167 Show all	TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		97 aa 10.2 kDa	Yes	0
RNF167-010 ENSP00000458905 ENST00000570328	I3L1K4 [Direct mapping] E3 ubiquitin-protein ligase RNF167 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		72 aa 7.6 kDa	No	0
RNF167-013 ENSP00000466753 ENST00000576965	K7EN24 [Direct mapping] E3 ubiquitin-protein ligase RNF167 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		74 aa 8.2 kDa	No	0
RNF167-016 ENSP00000460024 ENST00000572382	I3L2Y3 [Direct mapping] E3 ubiquitin-protein ligase RNF167 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	208 aa 23.3 kDa	No	1

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