Expression of SLC25A11 in cancer - Summary - The Human Protein Atlas

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SLC25A11

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SLC25A11
Gene description	Solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11
Protein class	Plasma proteins Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression, often with a granular pattern.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA021167
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and pancreatic cancer (favourable).
Renal cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA021167

GENE INFORMATION
Gene name	SLC25A11 (HGNC Symbol)
Synonyms	OGC, SLC20A4
Description	Solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11 (HGNC Symbol)
Entrez gene summary	The oxoglutarate/malate carrier transports 2-oxoglutarate across the inner membranes of mitochondria in an electroneutral exchange for malate or other dicarboxylic acids (summary by Iacobazzi et al., 1992 [PubMed 1457818]).[supplied by OMIM, Jan 2011]
Chromosome	17
Cytoband	p13.2
Chromosome location (bp)	4937130 - 4940251
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000108528 (version 83.38)
Entrez gene	8402
UniProt	Q02978 (UniProt - Evidence at protein level)
neXtProt	NX_Q02978
Antibodypedia	SLC25A11 antibodies

PROTEIN BROWSER

SLC25A11-001	SLC25A11-003	SLC25A11-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC25A11-001 ENSP00000225665 ENST00000225665	Q02978 [Direct mapping] Mitochondrial 2-oxoglutarate/malate carrier protein Q6IBH0 [Target identity:100%; Query identity:100%] SLC25A11 protein; Solute carrier family 25 (Mitochondrial carrier oxoglutarate carrier), member 11, isoform CRA_b; cDNA FLJ76014, highly similar to Homo sapiens solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11 (SLC25A11), mRNA Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005887 [integral component of plasma membrane] GO:0005975 [carbohydrate metabolic process] GO:0006006 [glucose metabolic process] GO:0006094 [gluconeogenesis] GO:0006810 [transport] GO:0015367 [oxoglutarate:malate antiporter activity] GO:0015742 [alpha-ketoglutarate transport] GO:0044281 [small molecule metabolic process] GO:0044822 [poly(A) RNA binding] Show all	314 aa 34.1 kDa	No	1
SLC25A11-003 ENSP00000440804 ENST00000544061	Q02978 [Direct mapping] Mitochondrial 2-oxoglutarate/malate carrier protein Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005887 [integral component of plasma membrane] GO:0005975 [carbohydrate metabolic process] GO:0006006 [glucose metabolic process] GO:0006094 [gluconeogenesis] GO:0006810 [transport] GO:0015367 [oxoglutarate:malate antiporter activity] GO:0015742 [alpha-ketoglutarate transport] GO:0044281 [small molecule metabolic process] GO:0044822 [poly(A) RNA binding] Show all	263 aa 28.5 kDa	No	1
SLC25A11-004 ENSP00000458993 ENST00000576951	I3L1P8 [Direct mapping] Mitochondrial 2-oxoglutarate/malate carrier protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0006810 [transport] GO:0016021 [integral component of membrane] Show all	296 aa 32.2 kDa	No	1

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