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CHRNE

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GENERAL INFORMATION

Gene name

 CHRNE

Gene description

 Cholinergic receptor, nicotinic, epsilon (muscle)

Protein class

 Disease related genes
Potential drug targets
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Group enriched (HMC-1, HEL)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (HMC-1, HEL)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 CHRNE (HGNC Symbol)

Synonyms

 ACHRE

Description

 Cholinergic receptor, nicotinic, epsilon (muscle) (HGNC Symbol)

Entrez gene summary

 Acetylcholine receptors at mature mammalian neuromuscular junctions are pentameric protein complexes composed of four subunits in the ratio of two alpha subunits to one beta, one epsilon, and one delta subunit. The acetylcholine receptor changes subunit composition shortly after birth when the epsilon subunit replaces the gamma subunit seen in embryonic receptors. Mutations in the epsilon subunit are associated with congenital myasthenic syndrome. [provided by RefSeq, Sep 2009]

Chromosome

 17

Cytoband

 p13.2

Chromosome location (bp)

 4897774 - 4903074

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000108556 (version 83.38)

Entrez gene

 1145

UniProt

 Q04844 (UniProt - Evidence at protein level)

neXtProt

 NX_Q04844

Antibodypedia

 CHRNE antibodies

PROTEIN BROWSER
CHRNE-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CHRNE-001
ENSP00000293780
ENST00000293780
Q04844 [Direct mapping]
Acetylcholine receptor subunit epsilon
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0003009 [skeletal muscle contraction]
GO:0004889 [acetylcholine-activated cation-selective channel activity]
GO:0005230 [extracellular ligand-gated ion channel activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005892 [acetylcholine-gated channel complex]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006812 [cation transport]
GO:0006936 [muscle contraction]
GO:0007165 [signal transduction]
GO:0007268 [synaptic transmission]
GO:0007271 [synaptic transmission, cholinergic]
GO:0007274 [neuromuscular synaptic transmission]
GO:0008324 [cation transmembrane transporter activity]
GO:0015464 [acetylcholine receptor activity]
GO:0016020 [membrane]
GO:0030054 [cell junction]
GO:0035094 [response to nicotine]
GO:0042166 [acetylcholine binding]
GO:0042391 [regulation of membrane potential]
GO:0043005 [neuron projection]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0050877 [neurological system process]
GO:0098655 [cation transmembrane transport]
Show all
 493 aa
54.7 kDa 		Yes 4

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.