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Malignant tissues exhibited moderate to strong granular cytoplasmic immunoreactivity. Many cases of renal cancers were weakly stained.
GENE INFORMATION
Gene name
C1QBP (HGNC Symbol)
Synonyms
gC1Q-R, gC1qR, HABP1, p32, SF2p32
Description
Complement component 1, q subcomponent binding protein (HGNC Symbol)
Entrez gene summary
The human complement subcomponent C1q associates with C1r and C1s in order to yield the first component of the serum complement system. The protein encoded by this gene is known to bind to the globular heads of C1q molecules and inhibit C1 activation. This protein has also been identified as the p32 subunit of pre-mRNA splicing factor SF2, as well as a hyaluronic acid-binding protein. [provided by RefSeq, Jul 2008]
Transporters SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001849 [complement component C1q binding] GO:0003714 [transcription corepressor activity] GO:0003729 [mRNA binding] GO:0005080 [protein kinase C binding] GO:0005515 [protein binding] GO:0005540 [hyaluronic acid binding] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006351 [transcription, DNA-templated] GO:0006397 [mRNA processing] GO:0006915 [apoptotic process] GO:0006955 [immune response] GO:0006958 [complement activation, classical pathway] GO:0007596 [blood coagulation] GO:0007597 [blood coagulation, intrinsic pathway] GO:0008134 [transcription factor binding] GO:0008380 [RNA splicing] GO:0009986 [cell surface] GO:0014065 [phosphatidylinositol 3-kinase signaling] GO:0016020 [membrane] GO:0016032 [viral process] GO:0030449 [regulation of complement activation] GO:0030984 [kininogen binding] GO:0031690 [adrenergic receptor binding] GO:0032689 [negative regulation of interferon-gamma production] GO:0032695 [negative regulation of interleukin-12 production] GO:0039534 [negative regulation of MDA-5 signaling pathway] GO:0039536 [negative regulation of RIG-I signaling pathway] GO:0042256 [mature ribosome assembly] GO:0043065 [positive regulation of apoptotic process] GO:0045087 [innate immune response] GO:0045785 [positive regulation of cell adhesion] GO:0048025 [negative regulation of mRNA splicing, via spliceosome] GO:0050687 [negative regulation of defense response to virus] GO:0051897 [positive regulation of protein kinase B signaling] GO:0070131 [positive regulation of mitochondrial translation] GO:0090023 [positive regulation of neutrophil chemotaxis] GO:0097177 [mitochondrial ribosome binding] GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading] GO:1901165 [positive regulation of trophoblast cell migration] GO:2000510 [positive regulation of dendritic cell chemotaxis]