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MED31

GENERAL INFORMATION

Gene name

 MED31

Gene description

 Mediator complex subunit 31

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Subcellular location is contradicted by limited external data.

Reliability score

 Uncertain based on 1 antibody.
HPA035947
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA035947

GENE INFORMATION

Gene name

 MED31 (HGNC Symbol)

Synonyms

 CGI-125, Soh1

Description

 Mediator complex subunit 31 (HGNC Symbol)

Entrez gene summary

Chromosome

 17

Cytoband

 p13.1

Chromosome location (bp)

 6643315 - 6651634

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000108590 (version 83.38)

Entrez gene

 51003

UniProt

 Q9Y3C7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y3C7

Antibodypedia

 MED31 antibodies

PROTEIN BROWSER
MED31-001
MED31-002
MED31-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MED31-001
ENSP00000225728
ENST00000225728
Q9Y3C7 [Direct mapping]
Mediator of RNA polymerase II transcription subunit 31
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000151 [ubiquitin ligase complex]
GO:0001104 [RNA polymerase II transcription cofactor activity]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0010467 [gene expression]
GO:0016567 [protein ubiquitination]
GO:0016592 [mediator complex]
GO:0048147 [negative regulation of fibroblast proliferation]
GO:0060173 [limb development]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070847 [core mediator complex]
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 131 aa
15.8 kDa 		No 0
MED31-002
ENSP00000458248
ENST00000575197
I3L0P8 [Direct mapping]
Mediator of RNA polymerase II transcription subunit 31
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0001104 [RNA polymerase II transcription cofactor activity]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0016592 [mediator complex]
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 43 aa
4.8 kDa 		No 0
MED31-004
ENSP00000459723
ENST00000574128
I3L2J1 [Direct mapping]
Mediator of RNA polymerase II transcription subunit 31
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0001104 [RNA polymerase II transcription cofactor activity]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0016592 [mediator complex]
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 57 aa
7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.