Cell atlas - DRG2 - The Human Protein Atlas

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DRG2

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm
	Vesicles

Human cell
	Cytosol
	Nucleoplasm
	Vesicles

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GENERAL INFORMATION
Gene name	DRG2
Gene description	Developmentally regulated GTP binding protein 2
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol & vesicles. In addition localized to the nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (approved), Cytosol (supported)
Additional location	In addition localized to the Nucleoplasm (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA007716
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol & vesicles. In addition localized to the nucleoplasm.

Main location

Vesicles (approved), Cytosol (supported)

Additional location

Nucleoplasm (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA007716	A-431	Nucleoplasm
			Vesicles
			Cytosol
	HPA007716	U-2 OS	Nucleoplasm	Spatial
			Vesicles	Spatial
			Cytosol	Spatial
	HPA007716	U-251 MG	Nucleoplasm
			Vesicles	Spatial
			Cytosol	Spatial

GENE INFORMATION
Gene name	DRG2
Synonyms
Description	Developmentally regulated GTP binding protein 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a GTP-binding protein known to function in the regulation of cell growth and differentiation. Read-through transcripts containing this gene and a downstream gene have been identified, but they are not thought to encode a fusion protein. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jan 2012]
Chromosome	17
Cytoband	p11.2
Chromosome location (bp)	18087886 - 18107971
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000108591 (version 83.38)
Entrez gene	1819
UniProt	P55039 (UniProt - Evidence at protein level)
neXtProt	NX_P55039
Antibodypedia	DRG2 antibodies

PROTEIN BROWSER

DRG2-001	DRG2-002	DRG2-011	DRG2-020	DRG2-025

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DRG2-001 ENSP00000225729 ENST00000225729	P55039 [Direct mapping] Developmentally-regulated GTP-binding protein 2 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0007165 [signal transduction] GO:0016020 [membrane] Show all	364 aa 40.7 kDa	No	0
DRG2-002 ENSP00000379076 ENST00000395726	A8MZF9 [Direct mapping] Developmentally-regulated GTP-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005525 [GTP binding] GO:0005737 [cytoplasm] Show all	343 aa 38.1 kDa	No	0
DRG2-011 ENSP00000462060 ENST00000580929	J3KRL5 [Direct mapping] Developmentally-regulated GTP-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		113 aa 12.4 kDa	No	0
DRG2-020 ENSP00000464076 ENST00000579601	J3QR71 [Direct mapping] Developmentally-regulated GTP-binding protein 2 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005525 [GTP binding] Show all	158 aa 16.9 kDa	No	0
DRG2-025 ENSP00000463256 ENST00000583355	J3QKV7 [Direct mapping] Developmentally-regulated GTP-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		161 aa 17.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.