Tissue expression of ICAM2 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	ICAM2
Gene description	Intercellular adhesion molecule 2
Protein class	CD markers Plasma proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	ICAM2 (HGNC Symbol)
Synonyms	CD102
Description	Intercellular adhesion molecule 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q23.3
Chromosome location (bp)	64002594 - 64020634
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000108622 (version 83.38)
Entrez gene	3384
UniProt	P13598 (UniProt - Evidence at protein level)
neXtProt	NX_P13598
Antibodypedia	ICAM2 antibodies

PROTEIN BROWSER

ICAM2-001	ICAM2-002	ICAM2-004	ICAM2-006	ICAM2-008	ICAM2-010	ICAM2-011	ICAM2-012	ICAM2-201	ICAM2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ICAM2-001 ENSP00000464665 ENST00000579788	P13598 [Direct mapping] Intercellular adhesion molecule 2 Q6FHE2 [Target identity:100%; Query identity:100%] ICAM2 protein; Intercellular adhesion molecule 2; Intercellular adhesion molecule 2 variant; Intercellular adhesion molecule 2, isoform CRA_a Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0016020 [membrane] GO:0016337 [single organismal cell-cell adhesion] GO:0030198 [extracellular matrix organization] GO:0045087 [innate immune response] GO:0050776 [regulation of immune response] GO:0070062 [extracellular exosome] Show all	275 aa 30.7 kDa	Yes	1
ICAM2-002 ENSP00000392634 ENST00000449662	P13598 [Direct mapping] Intercellular adhesion molecule 2 Q6FHE2 [Target identity:100%; Query identity:100%] ICAM2 protein; Intercellular adhesion molecule 2; Intercellular adhesion molecule 2 variant; Intercellular adhesion molecule 2, isoform CRA_a Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0016020 [membrane] GO:0016337 [single organismal cell-cell adhesion] GO:0030198 [extracellular matrix organization] GO:0045087 [innate immune response] GO:0050776 [regulation of immune response] GO:0070062 [extracellular exosome] Show all	275 aa 30.7 kDa	Yes	1
ICAM2-004 ENSP00000462579 ENST00000579687	P13598 [Direct mapping] Intercellular adhesion molecule 2 Q6FHE2 [Target identity:100%; Query identity:100%] ICAM2 protein; Intercellular adhesion molecule 2; Intercellular adhesion molecule 2 variant; Intercellular adhesion molecule 2, isoform CRA_a Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0016020 [membrane] GO:0016337 [single organismal cell-cell adhesion] GO:0030198 [extracellular matrix organization] GO:0045087 [innate immune response] GO:0050776 [regulation of immune response] GO:0070062 [extracellular exosome] Show all	275 aa 30.7 kDa	Yes	1
ICAM2-006 ENSP00000463199 ENST00000578379	J3QKR4 [Direct mapping] Intercellular adhesion molecule 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007155 [cell adhesion] GO:0016021 [integral component of membrane] GO:0016337 [single organismal cell-cell adhesion] Show all	174 aa 19.5 kDa	No	1
ICAM2-008 ENSP00000464372 ENST00000578892	J3QRT5 [Direct mapping] Intercellular adhesion molecule 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007155 [cell adhesion] GO:0016021 [integral component of membrane] GO:0016337 [single organismal cell-cell adhesion] Show all	251 aa 28.2 kDa	Yes	1
ICAM2-010 ENSP00000464331 ENST00000578313	J3QRQ1 [Direct mapping] Intercellular adhesion molecule 2 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007155 [cell adhesion] GO:0016020 [membrane] GO:0016337 [single organismal cell-cell adhesion] Show all	216 aa 24 kDa	Yes	0
ICAM2-011 ENSP00000463862 ENST00000584084	J3QQR8 [Direct mapping] Intercellular adhesion molecule 2 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007155 [cell adhesion] GO:0016020 [membrane] GO:0016337 [single organismal cell-cell adhesion] Show all	167 aa 18.5 kDa	Yes	0
ICAM2-012 ENSP00000463945 ENST00000583366	J3QQX6 [Direct mapping] Intercellular adhesion molecule 2 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007155 [cell adhesion] GO:0016020 [membrane] GO:0016337 [single organismal cell-cell adhesion] Show all	214 aa 23.7 kDa	Yes	0
ICAM2-201 ENSP00000415283 ENST00000412356	P13598 [Direct mapping] Intercellular adhesion molecule 2 Q6FHE2 [Target identity:100%; Query identity:100%] ICAM2 protein; Intercellular adhesion molecule 2; Intercellular adhesion molecule 2 variant; Intercellular adhesion molecule 2, isoform CRA_a Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001931 [uropod] GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007155 [cell adhesion] GO:0016020 [membrane] GO:0016337 [single organismal cell-cell adhesion] GO:0030198 [extracellular matrix organization] GO:0045087 [innate immune response] GO:0050776 [regulation of immune response] GO:0070062 [extracellular exosome] GO:0071944 [cell periphery] Show all	275 aa 30.7 kDa	Yes	1
ICAM2-202 ENSP00000388666 ENST00000418105	P13598 [Direct mapping] Intercellular adhesion molecule 2 Q6FHE2 [Target identity:100%; Query identity:100%] ICAM2 protein; Intercellular adhesion molecule 2; Intercellular adhesion molecule 2 variant; Intercellular adhesion molecule 2, isoform CRA_a Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0016020 [membrane] GO:0016337 [single organismal cell-cell adhesion] GO:0030198 [extracellular matrix organization] GO:0045087 [innate immune response] GO:0050776 [regulation of immune response] GO:0070062 [extracellular exosome] Show all	275 aa 30.7 kDa	Yes	1