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Colorectal, prostate, lymphomas as well as a few cases of urothelial cancer and cholangiocarcinomas showed moderate to strong cytoplasmic staining. Carcinoids, gliomas, melanomas, testicular and skin cancers were mainly negative. Remaining tumors showed weak to moderate cytoplasmic positivity.
GENE INFORMATION
Gene name
SYNGR2
Synonyms
Description
Synaptogyrin 2 (HGNC Symbol)
Entrez gene summary
This gene encodes an integral membrane protein containing four transmembrane regions and a C-terminal cytoplasmic tail that is tyrosine phosphorylated. The exact function of this protein is unclear, but studies of a similar rat protein suggest that it may play a role in regulating membrane traffic in non-neuronal cells. The gene belongs to the synaptogyrin gene family. [provided by RefSeq, Jul 2008]