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CYTH1

GENERAL INFORMATION

Gene name

 CYTH1

Gene description

 Cytohesin 1

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (favourable).
Head and neck cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 CYTH1 (HGNC Symbol)

Synonyms

 B2-1, cytohesin-1, D17S811E, PSCD1

Description

 Cytohesin 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This gene is highly expressed in natural killer and peripheral T cells, and regulates the adhesiveness of integrins at the plasma membrane of lymphocytes. A pseudogene of this gene has been defined on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Chromosome

 17

Cytoband

 q25.3

Chromosome location (bp)

 78674048 - 78782297

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000108669 (version 83.38)

Entrez gene

 9267

UniProt

 Q15438 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15438

Antibodypedia

 CYTH1 antibodies

PROTEIN BROWSER
CYTH1-001
CYTH1-002
CYTH1-005
CYTH1-006
CYTH1-012
CYTH1-015
CYTH1-016
CYTH1-018
CYTH1-020
CYTH1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CYTH1-001
ENSP00000389095
ENST00000446868
Q15438 [Direct mapping]
Cytohesin-1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005086 [ARF guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0008289 [lipid binding]
GO:0016192 [vesicle-mediated transport]
GO:0030155 [regulation of cell adhesion]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0032012 [regulation of ARF protein signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 398 aa
46.4 kDa 		No 0
CYTH1-002
ENSP00000465665
ENST00000591455
Q15438 [Direct mapping]
Cytohesin-1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005086 [ARF guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0008289 [lipid binding]
GO:0016192 [vesicle-mediated transport]
GO:0030155 [regulation of cell adhesion]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0032012 [regulation of ARF protein signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 397 aa
46.4 kDa 		No 0
CYTH1-005
ENSP00000468433
ENST00000586043
K7ERV8 [Direct mapping]
Cytohesin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005086 [ARF guanyl-nucleotide exchange factor activity]
GO:0032012 [regulation of ARF protein signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 194 aa
22.4 kDa 		No 0
CYTH1-006
ENSP00000466949
ENST00000590300
K7ENH6 [Direct mapping]
Cytohesin-1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005086 [ARF guanyl-nucleotide exchange factor activity]
GO:0032012 [regulation of ARF protein signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 86 aa
10 kDa 		No 0
CYTH1-012
ENSP00000465252
ENST00000589296
K7EJN5 [Direct mapping]
Cytohesin-1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 64 aa
7.6 kDa 		No 0
CYTH1-015
ENSP00000466512
ENST00000589297
Q15438 [Direct mapping]
Cytohesin-1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005086 [ARF guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0008289 [lipid binding]
GO:0016192 [vesicle-mediated transport]
GO:0030155 [regulation of cell adhesion]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0032012 [regulation of ARF protein signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 339 aa
39.5 kDa 		No 0
CYTH1-016
ENSP00000465940
ENST00000585509
Q15438 [Direct mapping]
Cytohesin-1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005086 [ARF guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0008289 [lipid binding]
GO:0016192 [vesicle-mediated transport]
GO:0030155 [regulation of cell adhesion]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0032012 [regulation of ARF protein signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 339 aa
39.5 kDa 		No 0
CYTH1-018
ENSP00000467052
ENST00000589768
K7ENQ8 [Direct mapping]
Cytohesin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005086 [ARF guanyl-nucleotide exchange factor activity]
GO:0032012 [regulation of ARF protein signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 272 aa
31.7 kDa 		No 0
CYTH1-020
ENSP00000465530
ENST00000587308
K7EKA2 [Direct mapping]
Cytohesin-1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005086 [ARF guanyl-nucleotide exchange factor activity]
GO:0032012 [regulation of ARF protein signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 104 aa
12.2 kDa 		No 0
CYTH1-201
ENSP00000354398
ENST00000361101
Q15438 [Direct mapping]
Cytohesin-1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005086 [ARF guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005923 [bicellular tight junction]
GO:0008289 [lipid binding]
GO:0016192 [vesicle-mediated transport]
GO:0030155 [regulation of cell adhesion]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0032012 [regulation of ARF protein signal transduction]
GO:0043547 [positive regulation of GTPase activity]
GO:0090162 [establishment of epithelial cell polarity]
Show all
 398 aa
46.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.