Expression of LGALS3BP in cancer - Summary

GENERAL INFORMATION
Gene name	LGALS3BP
Gene description	Lectin, galactoside-binding, soluble, 3 binding protein
Protein class	Cancer-related genes Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (SK-BR-3)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in a few tissues. Additional secreted positivity in secretory glandular epithelia.

ANTIBODY IHC RELIABILITY
Data reliability description	Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Supported based on 2 antibodies. HPA000554 , CAB002158
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA000554	CAB002158

GENE INFORMATION
Gene name	LGALS3BP (HGNC Symbol)
Synonyms	90K, BTBD17B, CyCAP, gp90, M2BP, MAC-2-BP, TANGO10B
Description	Lectin, galactoside-binding, soluble, 3 binding protein (HGNC Symbol)
Entrez gene summary	The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS3BP has been found elevated in the serum of patients with cancer and in those infected by the human immunodeficiency virus (HIV). It appears to be implicated in immune response associated with natural killer (NK) and lymphokine-activated killer (LAK) cell cytotoxicity. Using fluorescence in situ hybridization the full length 90K cDNA has been localized to chromosome 17q25. The native protein binds specifically to a human macrophage-associated lectin known as Mac-2 and also binds galectin 1. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q25.3
Chromosome location (bp)	78971238 - 78980109
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000108679 (version 83.38)
Entrez gene	3959
UniProt	Q08380 (UniProt - Evidence at protein level)
neXtProt	NX_Q08380
Antibodypedia	LGALS3BP antibodies

PROTEIN BROWSER

LGALS3BP-001	LGALS3BP-007	LGALS3BP-010	LGALS3BP-017	LGALS3BP-018	LGALS3BP-020	LGALS3BP-021

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LGALS3BP-001 ENSP00000262776 ENST00000262776	Q08380 [Direct mapping] Galectin-3-binding protein Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005044 [scavenger receptor activity] GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0006898 [receptor-mediated endocytosis] GO:0006968 [cellular defense response] GO:0007155 [cell adhesion] GO:0007165 [signal transduction] GO:0016020 [membrane] GO:0031012 [extracellular matrix] GO:0070062 [extracellular exosome] GO:0072562 [blood microparticle] Show all	585 aa 65.3 kDa	Yes	0
LGALS3BP-007 ENSP00000465120 ENST00000591778	K7EJD3 [Direct mapping] Galectin-3-binding protein Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005044 [scavenger receptor activity] GO:0006898 [receptor-mediated endocytosis] GO:0016020 [membrane] Show all	205 aa 22 kDa	Yes	0
LGALS3BP-010 ENSP00000465380 ENST00000589906	K7EJY8 [Direct mapping] Galectin-3-binding protein Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005044 [scavenger receptor activity] GO:0006898 [receptor-mediated endocytosis] GO:0016020 [membrane] Show all	144 aa 15.6 kDa	Yes	0
LGALS3BP-017 ENSP00000468586 ENST00000591274	K7ES75 [Direct mapping] Galectin-3-binding protein Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005044 [scavenger receptor activity] GO:0006898 [receptor-mediated endocytosis] GO:0016020 [membrane] Show all	88 aa 9.5 kDa	Yes	0
LGALS3BP-018 ENSP00000468774 ENST00000589775	K7ESM3 [Direct mapping] Galectin-3-binding protein Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005044 [scavenger receptor activity] GO:0006898 [receptor-mediated endocytosis] GO:0016020 [membrane] Show all	209 aa 22.5 kDa	Yes	0
LGALS3BP-020 ENSP00000467211 ENST00000589527	K7EP36 [Direct mapping] Galectin-3-binding protein Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005044 [scavenger receptor activity] GO:0005515 [protein binding] GO:0006898 [receptor-mediated endocytosis] GO:0016020 [membrane] Show all	259 aa 28.3 kDa	Yes	0
LGALS3BP-021 ENSP00000465729 ENST00000585407	K7EKQ5 [Direct mapping] Galectin-3-binding protein Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005044 [scavenger receptor activity] GO:0006898 [receptor-mediated endocytosis] GO:0016020 [membrane] Show all	210 aa 22.7 kDa	Yes	0