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ASIC2

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GENERAL INFORMATION

Gene name

 ASIC2

Gene description

 Acid sensing (proton gated) ion channel 2

Protein class

 Plasma proteins
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (NTERA-2)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (NTERA-2)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 ASIC2 (HGNC Symbol)

Synonyms

 ACCN, ACCN1, ASIC2a, BNaC1, BNC1, hBNaC1, MDEG

Description

 Acid sensing (proton gated) ion channel 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene may play a role in neurotransmission. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 3 has been observed to co-assemble into proton-gated channels sensitive to gadolinium. Alternative splicing has been observed at this locus and two variants, encoding distinct isoforms, have been identified. [provided by RefSeq, Feb 2012]

Chromosome

 17

Cytoband

Chromosome location (bp)

 33013087 - 34174964

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000108684 (version 83.38)

Entrez gene

 40

UniProt

 Q16515 (UniProt - Evidence at protein level)

neXtProt

 NX_Q16515

Antibodypedia

 ASIC2 antibodies

PROTEIN BROWSER
ASIC2-001
ASIC2-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ASIC2-001
ENSP00000225823
ENST00000225823
Q16515 [Direct mapping]
Acid-sensing ion channel 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Show all
GO:0003026 [regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback]
GO:0005216 [ion channel activity]
GO:0005261 [cation channel activity]
GO:0005272 [sodium channel activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006812 [cation transport]
GO:0006814 [sodium ion transport]
GO:0007268 [synaptic transmission]
GO:0007417 [central nervous system development]
GO:0007422 [peripheral nervous system development]
GO:0007602 [phototransduction]
GO:0007605 [sensory perception of sound]
GO:0009612 [response to mechanical stimulus]
GO:0010447 [response to acidic pH]
GO:0010468 [regulation of gene expression]
GO:0015280 [ligand-gated sodium channel activity]
GO:0015672 [monovalent inorganic cation transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019229 [regulation of vasoconstriction]
GO:0022839 [ion gated channel activity]
GO:0030193 [regulation of blood coagulation]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0035418 [protein localization to synapse]
GO:0035725 [sodium ion transmembrane transport]
GO:0042391 [regulation of membrane potential]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043066 [negative regulation of apoptotic process]
GO:0043197 [dendritic spine]
GO:0045202 [synapse]
GO:0050915 [sensory perception of sour taste]
GO:0050974 [detection of mechanical stimulus involved in sensory perception]
GO:0051965 [positive regulation of synapse assembly]
GO:0055085 [transmembrane transport]
GO:0098655 [cation transmembrane transport]
Show all
 563 aa
62.9 kDa 		No 2
ASIC2-003
ENSP00000352934
ENST00000359872
Q16515 [Direct mapping]
Acid-sensing ion channel 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Show all
GO:0005272 [sodium channel activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006814 [sodium ion transport]
GO:0007268 [synaptic transmission]
GO:0007417 [central nervous system development]
GO:0007422 [peripheral nervous system development]
GO:0010468 [regulation of gene expression]
GO:0015280 [ligand-gated sodium channel activity]
GO:0015672 [monovalent inorganic cation transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030193 [regulation of blood coagulation]
GO:0034220 [ion transmembrane transport]
GO:0035725 [sodium ion transmembrane transport]
GO:0050915 [sensory perception of sour taste]
GO:0055085 [transmembrane transport]
Show all
 512 aa
57.7 kDa 		No 2

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.